Definition 1 | Definition 2 | |||
---|---|---|---|---|
Characteristic, n (%) | Early responders | Not early responders | Early responders | Not early responders |
n = 363 | n = 237 | n = 417 | n = 173 | |
Age, years, mean (SD) [median] | 58.5 (17.72) [58.0] | 58.2 (17.17) [59.0] | 58.9 (17.78) [58.0] | 57.2 (17.08) [58.5] |
<65 years | 227 (62.5) | 146 (61.6) | 253 (60.7) | 114 (65.9) |
≥65 years | 136 (37.5) | 90 (38.0) | 164 (39.3) | 58 (33.5) |
Sex, male | 211 (58.1) | 143 (60.3) | 239 (57.3) | 108 (62.4) |
Relevant medical conditions affecting <10% of patients at hospitalization (initial visit*), n (%) | ||||
Diabetes | 83 (22.9) | 75 (31.6) | 103 (24.7) | 50 (28.9) |
Cancer/malignancy | 62 (17.1) | 29 (12.2) | 69 (16.5) | 19 (11.0) |
Peripheral vascular disease | 55 (15.2) | 37 (15.6) | 68 (16.3) | 20 (11.6) |
Congestive heart disease | 47 (12.9) | 30 (12.7) | 58 (13.9) | 18 (10.4) |
Other relevant conditions† | 100 (27.5 ) | 84 (35.4) | 121 (29.0) | 57 (32.9) |
Unknown | 1 (0.3) | 1 (0.4) | 1 (0.2) | 1 (0.6) |
Age of patients with comorbidities, years, mean (SD) [median] | 62.2 (16.3) [62.0] | 62.0 (15.1) [62.0] | 62.8 (16.2) [63.5] | 60.6 (15.2) [60.0] |
Immunosuppressants/Immunomodulators in the 3 months prior to hospitalization, n (%) | 35 (9.6) | 17 (7.2) | 40 (9.6) | 11 (6.4) |
Type of lesion‡ | ||||
Cellulitis/fasciitis | 252 (69.4) | 155 (65.4) | 280 (67.1) | 122 (70.5) |
Abscess | 77 (21.2) | 45 (19.0) | 86 (20.6) | 34 (19.7) |
Post-traumatic wound | 40 (11.0) | 18 (7.6) | 48 (11.5) | 10 (5.8) |
Post-surgical wound | 40 (11.0) | 30 (12.7) | 50 (12.0) | 19 (11.0) |
Diabetic leg ulcer | 19 (5.2) | 24 (10.1) | 27 (6.5) | 16 (9.2) |
Peripheral vascular disease ulcer | 14 (3.9) | 20 (8.4) | 19 (4.6) | 14 (8.1) |
Lesion extension >50 cm2 | 61 (16.8) | 49 (20.7) | 73 (17.5) | 36 (20.8) |
Lower extremities affected | 227 (62.5) | 180 (75.9) | 265 (63.5) | 134 (77.5) |
Swelling/induration | 239 (65.8) | 173 (73.0) | 273 (65.5) | 132 (76.3) |
Skin necrosis | 28 (7.7) | 35 (14.8) | 38 (9.1) | 24 (13.9) |
Recurrent skin infection episode§ | 75 (20.7) | 55 (23.2) | 83 (19.9) | 43 (24.9) |
Nosocomial infection | 30 (8.3) | 22 (9.3) | 35 (8.4) | 17 (9.8) |