Figure 1

Alignment of the deduced amino acid sequences of domain HA1 of subtype H1 of viral isolates found in Uberlândia. HA1 domain sequences of 2002 H1N2 and 2006 H1N1 viruses of samples collected in Uberlândia were compared to the sequence of the vaccine strain A/New Caledonia/20/99 (accession number AJ344014) that was available in the same period of sample collection. Residues that match the residues of the vaccine sequence shown at the top are represented by dots and those divergent are shown. Residues involved in receptor binding are shaded, sialic acid binding sites are underlined, antigenic sites Ca₁, Ca₂, Cb, Sa and Sb are shown as open boxes, and N-linked glycosylation sites are marked as dashed open boxes. The numbering above the alignment represents the positions of amino acid residues of H1 protein according to the reference sequence A/New York/399/2003 (H1N1) (accession number CY002808). * sequences of viruses detected in samples 213, 214, 215, 228, 232, and 241.