TY - JOUR AU - Li, Xiu-Zhen AU - Wang, Xiao-Hu AU - Xia, Li-Jun AU - Weng, Ya-Biao AU - Hernandez, Jorge A. AU - Tu, Li-Qing AU - Li, Lu-Tao AU - Li, Shou-Jun AU - Yuan, Zi-Guo PY - 2015 DA - 2015/03/04 TI - Protective efficacy of recombinant canine adenovirus type-2 expressing TgROP18 (CAV-2-ROP18) against acute and chronic Toxoplasma gondii infection in mice JO - BMC Infectious Diseases SP - 114 VL - 15 IS - 1 AB - The use of recombinant viral vectors expressing T. gondii antigens is a safe and efficient approach to induce immune responses against the parasite, as well as a valuable tool for vaccine development. We have previously prolonged the survival time of mice challenged with the RH strain of T. gondii by immunizing the mice with a eukaryotic vector expressing the protein ROP18 of T. gondii. We are now looking for ways to improve this vaccination strategy and enhance protection. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-015-0815-1 DO - 10.1186/s12879-015-0815-1 ID - Li2015 ER -