Table 3 Risk factors for herpes zoster
From: The epidemiology of herpes zoster and its complications in Medicare cancer patients
Variable | Hematologic cancers | Solid cancers | ||||
|---|---|---|---|---|---|---|
(n = 82,832) | (n = 944,777) | |||||
Incidence rate ratio | 95% CI1 | P-value | Incidence rate ratio | 95% CI1 | P-value | |
Age at diagnosis (ref = 85+ years old) | ||||||
65 to 75 years old | 1.05 | (1.00 - 1.10) | 0.067 | 0.97 | (0.94 - 1.00) | 0.025 |
75 to 85 years old | 1.12 | (1.07 - 1.18) | <0.001 | 1.04 | (1.01 - 1.07) | 0.014 |
Male (ref = female) | 0.83 | (0.81 - 0.85) | <0.001 | 0.80 | (0.78 - 0.81) | <0.001 |
Race (ref = white) | ||||||
Black | 0.64 | (0.50 - 0.81) | <0.001 | 0.60 | (0.51 - 0.70) | <0.001 |
Asian/Pacific Islander | 1.25 | (0.98 - 1.60) | 0.074 | 1.28 | (1.08 - 1.51) | 0.003 |
North American Native/Alaska Native | 1.06 | (0.77 - 1.46) | 0.730 | 0.92 | (0.74 - 1.16) | 0.488 |
Other or Unknown | 1.11 | (0.87 - 1.43) | 0.398 | 1.16 | (0.98 - 1.37) | 0.089 |
Diabetes | 1.02 | (0.98 - 1.07) | 0.344 | 0.99 | (0.96 - 1.01) | 0.225 |
HIV-positive (ref = HIV-negative) | 0.82 | (0.41 - 1.65) | 0.587 | 1.16 | (0.78 - 1.72) | 0.451 |
Other immunocompromising conditions and/or medications2 | 1.25 | (1.20 - 1.30) | <0.001 | 1.26 | (1.23 - 1.28) | <0.001 |
Cancer patient | 2.35 | (2.29 - 2.42) | <0.001 | 1.18 | (1.15 - 1.21) | <0.001 |
Receipt of autologous stem cell transplant | 2.07 | (1.49 - 2.89) | <0.001 | N/A | ||
Receipt of allogeneic stem cell transplant | 1.92 | (1.09 - 3.38) | 0.024 | |||
Receipt of radiotherapy | N/A | 0.94 | (0.93 - 0.96) | <0.001 | ||
Stage I/II at diagnosis | 1.01 | (0.99 - 1.03) | 0.269 | |||
Stage III/IV at diagnosis | 1.20 | (1.16 - 1.23) | <0.001 | |||