From: How much European prescribing physicians know about invasive fungal infections management?
Question | Adequate answer | Overall | Medical | ICU | P | Residents | Staff | P |
---|---|---|---|---|---|---|---|---|
N = 121 | n = 62 | N = 52 | n = 67 | n = 54 | ||||
Q1.When Candida is isolated in a urine culture, choose the answer that best describes what you would do: | Start antifungal treatment only in some cases. | 69.4 | 79 | 63.5 | 0.09 | 62.7 | 77.8 | 0.08 |
Q2.On a patient with mechanical ventilation and a probable VAP a tracheal aspirate culture shows Candida sp. Which of the following statements best show your interpretation: | Requires antifungal treatment only if the patient has a high Candida score. | 42.1 | 46.5 | 38.5 | 0.44 | 38.8 | 46.3 | 0.46 |
Q3. In which of the following clinical scenarios you would start Candida prophylaxis? | AML (Acute Myeloid Leukemia) patients on induction chemotherapy. | 38 | 45.2 | 32.7 | 0.18 | 29.9 | 48.1 | 0.05 |
Q4.In your opinion, the best choice for Candida prophylaxis is:. | Fluconazole in most of the cases. | 88.4 | 83.9 | 92.3 | 0.25 | 85.1 | 92.6 | 0.25 |
Q5.In a patient with sepsis possibly caused by a femoral catheter infection, you would prescribe… | Treatment against Gram positive and Gram negative bacteria and yeasts. | 41.3 | 51.6 | 28.8 | 0.02 | 56.7 | 22.2 | <0.001 |
Q6 .A microbiologist informs you that there are yeasts at the gram stain of a blood culture, so you… | Start antifungal treatment immediately. | 81.8 | 77.4 | 86.5 | 0.23 | 77.6 | 87 | 0.23 |
Q7.In a patient with candidemia, which antifungal would be your first choice before knowing the species of Candida? | Candin or Fluconazole. | 90.1 | 88.7 | 92.3 | 0.75 | 88.1 | 92.6 | 0.54 |
Q8 .Choose the right answer among the following statements: | All of the above are true: Candida glabrata can be resistant to fluconazole. Candida krusei is always resistant to fluconazole. Candida parapsilosis is associated to catheter infection. Candida albicans is usually susceptible to fluconazole. | 75.2 | 75.8 | 73.1 | 0.83 | 73.1 | 77.8 | 0.67 |
Q9.During the follow-up of candidemic patients, it is advised to: | All of the above are true: Draw blood cultures after 3–7 days of antifungal treatment; exclude infective endocarditis by transesophageal echocardiography; perform an eye fundus examination; consider sequential treatment switching to an oral azole when clinically safe. | 83.5 | 85.5 | 80.8 | 0.61 | 80.6 | 87 | 0.46 |
Q10. In the treatment of candidemia by a fluconazole-susceptible Candida, you would usually prescribe: | Fluconazole 400 to 800Â mg per day depending on the Candida species. | 64.5 | 74.2 | 53.8 | 0.03 | 62.7 | 66.7 | 0.7 |
Q11.Which do you think is the percentage of fluconazole resistance in Candida strains isolated from blood cultures at your hospital? | Less than 5%. | 24 | 19.4 | 28.8 | 0.27 | 23.9 | 24.1 | 1 |
Q12.In which of the following scenarios would you choose L-AmB as your first choice? | In unspecified invasive filamentous fungal infection. | 47.1 | 51.6 | 44.2 | 0.45 | 35.8 | 61.1 | <0.006 |
Q13. Regarding the treatment with azoles and candins, which of the following statements is true: | Candins can be used as empirical treatment before knowing the yeast antifungal susceptibility. | 67.8 | 64.5 | 75 | 0.30 | 53.7 | 85.2 | <0.001 |
Q14.When isolating Aspergillus spp. in a respiratory sample, you would consider: | Treatment in patients who fulfilled criteria of proven or probable invasive aspergillosis | 52.1 | 74.2 | 26.9 | <0.01 | 49.3 | 55.6 | 0.58 |
Q15.Which of the following statements regarding the Galactomannan test is false: | It can only be performed in serum samples. | 42 | 50.8 | 35.3 | 0.13 | 36.9 | 48.1 | 0.26 |
Q16.Which of the following are considered invasive aspergillosis radiological findings? | All of the above are true: Presence of dense, well-circumscribed lesions with or without a halo sign in a thoracic CT scanner; presence of a cavity in a thoracic CT scanner; presence of an air-crescent sign in a thoracic CT scanner; sinusitis. | 58.7 | 67.7 | 51.9 | 0.12 | 59.7 | 57.4 | 0.85 |
Q17.In a patient with invasive pulmonary aspergillosis, which antifungal treatment would you choose before having the antifungal susceptibility data? | Voriconazole | 57 | 56.5 | 61.5 | 0.70 | 43.3 | 74.1 | <0.001 |
Q18.In your opinion, which are the indications of combined antifungal therapy in invasive aspergillosis? | It is recommended as rescue therapy when previous antifungal treatment has failed. | 38.8 | 43.5 | 30.8 | 0.17 | 32.8 | 46.3 | 0.14 |
Q19.What is your opinion concerning the measurement of antifungal levels? | All of the above are true: Up-to-date guidelines do not recommend its systematical determination; it can be useful to identify azoles under-dosed patients; there is no indication to determine serum levels of L-AmB; it can help to identify azoles related toxicity. | 62 | 67.7 | 55.8 | 0.24 | 56.7 | 68.5 | 0.19 |
Q20.In your opinion, which would be the proper length of treatment of aspergillosis in a solid organ recipient | A minimum of 6 to 12Â weeks. | 36.7 | 37.1 | 33.3 | 0.7 | 34.8 | 38.9 | 0.7 |