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Table 2 Factors associated with positive LTBI screening test results

From: Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON®-TB Gold In-tube

 

TST

QFT-GIT

HBHA-IGRA

 

p

OR [CI 95%])

p

OR [CI 95%]

p

OR [CI 95%]

Mtb exposure

0.0455

11.8 [0.6-232]

0.4455

2.2 [0.5-10.3]

0.0353

9.9 [1.1-90.7]

BCG

0.2273

6.0 [0.2-136]

1

0.7 [0.1-5.0]

0.0318

15 [0.7-307]

CD4+ T-cell count

0.8773

NA

0.7777

NA

0.6021

NA

Viral load

0.1844

NA

0.0261

NA

0.0752

NA

  1. A non-random association between positive test results and 1) the presence of an Mtb exposure risk factor, 2) BCG vaccination status, 3) CD4+ T-cell counts and 4) viral loads was assessed for the TST, the QFT-GIT and the HBHA-IGRA. Fisher’s exact test and odds ratio (OR) with a 95% confidence interval (CI 95%) was applied for the dichotomous variables (presence or not of an Mtb exposure risk factor and BCG vaccination status). Chi-squared test for trend was used for CD4+ T-cell counts and viral loads organized into ordinal variables (CD4+ T-cell counts <50; 50–199; 200–499, >500 cell/mm3 and viral loads <40, 40–10000; 10000–100000; >100000 copies/ml). Significant p values are in bold type (p < 0.05).