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Table 3 Treatment and outcome of patients with and without sputum SPCN

From: Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan

 

SPCN (+)

SPCN (−)

P value

N = 111

N = 689

 

Treatment regimen

   

  Isoniazide (days)

289 ± 90

234 ± 71

p < 0.001

  Rifampicin (days)

284 ± 91

235 ± 69

p < 0.001

  Ethambutol (days)

228 ± 105

191 ± 96

p = 0.001

  Pyrazinamide (days)

137 ± 136

90 ± 74

p = 0.001

  Streptomycin (days) (total cases)

84 ± 76 (18)

43 ± 34 (39)

p = 0.036

  Levofloxacin (days) (total cases)

132 ± 141 (11)

172 ± 196 (17)

p = 0.559

  Moxifloxacin (days) (total cases)

215 ± 120 (6)

162 ± 146 (13)

p = 0.456

Treatment days after final positive culture

261 ± 72

220 ± 73

p < 0.001

DOT

92 (83)

475 (69)

p = 0.001

Complete treatment

109 (98)

679 (99)

p = 0.677

Sputum smear and culture status during treatment

After treatment for 2 months

  Smear positive

84 (76)

32 (5)

p < 0.001*

  Culture positive

22 (20)

50 (7)

p < 0.001*

After treatment for 5 months

   

  Smear positive

26 (23)

9 (1)

p < 0.001*

  Culture positive

1 (1)

14 (2)

p = 0.707*

After treatment for 9 months

   

  Smear positive

6 (5)

4 (1)

p = 0.001*

  Culture positive

0 (0)

6 (1)

p = 0.407*

Relapse within 3 years

3 (3)

7 (1)

p = 0.150*

  1. Data are presented as N (%) or mean ± standard deviation; SPCN, smear-positive but culture-negative; DOT, directly observed therapy.
  2. *Fisher’s exact test.