Genetic diversity of medically important and emergingCandidaspp. based on rDNA ITS sequences. (A) The median-joining haplotype network of 319 DNA sequences of clinical (n = 300) and reference/type strains (n = 19) belonging to 17 Candida species and 1 non-Candida species (Lodderomyces elongisporus). Each circle represents one haplotype (H1-H67), and the circle circumference is proportional to the haplotype frequency of the dataset. The black dots (median vectors, m) represent unsampled or extinct haplotypes in the population. Mutational steps are represented by lines between haplotypes and, in cases of long branches, by values. (B) The haplotypes are color-coded, and each color represents the predominantly associated source of acquired infection for the haplotype (endogenous versus exogenous).