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Table 7 Antibiotic susceptibilities of pneumococcal meningitis isolates among children <16 years and adults ≥16 years in Germany from 1992/93 to 2012/13

From: Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany

 

Children <16 years

Adults ≥16 years

CLSI breakpoints (mg/L)

 

I%

R%

n

I%

R%

n

I

R

Penicillin G, meningitis

0.0

7.2

1,317

0.0

7.2

1,731

-

≥0.12

Cefotaxime, meningitis

0.8

0.5

1,317

0.9

0.2

1,729

1

≥2

Macrolides*

0.1

19.8

1,317

0.1

10.8

1,730

0.5

≥1

Clindamycin

0.2

5.9

1,316

0.5

5.7

1,730

0.5

≥1

Tetracycline

0.4

9.2

1,316

0.9

8.9

1,731

2

≥4

Levofloxacin

0.2

0.3

874

0.2

0.1

1,326

4

≥8

SXT

6.1

5.7

870

7.1

5.5

1,318

1/19-2/38

≥4/76

  1. I, intermediately-resistant; R, resistant; n, number of isolates. SXT, trimethoprim-sulfamethoxazole. MIC breakpoints according to CLSI M100-S24, 2014 [20].
  2. *Macrolides: erythromycin or clarithromycin.
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BMC Infectious Diseases

ISSN: 1471-2334

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