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Figure 2 | BMC Infectious Diseases

Figure 2

From: Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany

Figure 2

Number of IPD isolates sent to the NRCS and number of pneumococcal meningitis cases contained. a Number of IPD isolates from children sent to the NRCS (n = 3,892) and number of pneumococcal meningitis cases contained (n = 1,320) per pneumococcal season from 1992/93 to 2012/13 (left Y-axis). The percentage of meningitis cases is indicated on the right Y-axis and trendlines are added for the pre- (1997/98-2005/06, slope −0.17) and the post-vaccination era (2007/08-2012/13, slope −0.16). The difference between the trendlines was highly significant (p<0.0001). b Number of IPD isolates from adults sent to the NRCS (n = 18,312) and number of pneumococcal meningitis cases contained (n = 1,766) per pneumococcal season from 1992/93 to 2012/13 (left Y-axis). The percentage of meningitis cases is indicated on the right Y-axis and trendlines are added for the pre- (1997/98-2005/06, slope −0.32) and the post-vaccination era (2007/08-2012/13, slope −0.79). Both the overall proportion and difference between the trendlines were highly significant (p<0.0001).

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