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Table 6 Functional enrichment classification of identified host-specific proteins using DAVID bioinformatics tool

From: Identification of circulating biomarkers in sera of Plasmodium knowlesi-infected malaria patients – comparison against Plasmodium vivax infection

  

Enrichment score+

Protein count (%)

Protein ID

P value

Biological process

Regulation of response to external stimulus

2.3

3 (27.27)

AHSG, C3, HRG

4.69e-3

 

Cellular iron ion homeostasis

2.13

3 (27.27)

HAP, HPX, TF

1.81e-4

 

Iron ion homeostasis

2.13

3 (27.27)

HAP, HPX, TF

2.45e-4

 

Cellular di-, tri-valent inorganic cation homeostasis

2.13

3 (27.27)

HAP, HPX, TF

9.34e.3

 

Di-, tri-valent inorganic cation homeostasis

2.13

3 (27.27)

HAP, HPX, TF

1.03e-2

 

Cellular cation homeostasis

2.13

3 (27.27)

HAP, HPX,TF

1.16e-2

Molecular function

Endopeptidase inhibitor activity

2.3

3 (27.27)

AHSG,C3, HRG

3.32e-3

 

Peptidase inhibitor activity

2.3

3 (27.27)

AHSG, C3, HRG

3.69e-3

 

Enzyme inhibitor activity

2.3

3 (27.27)

AHSG, C3, HRG

1.11e-2

Cellular component

Extracellular region

8.11

11 (100)

A1BG, AHSG, APOA1, AZGP1, C3, FGG, HAP, HPX, HRG, LRG1, TF

2.66e-11

 

Secretory granule

2.31

4 (36.36)

APOA1, FGG, HRG, TF

3.06e-4

 

Cytoplasmic membrane-bounded vesicle

2.31

4 (36.36)

APOA1, FGG, HRG, TF

7.58e-3

 

Membrane-bounded vesicle

2.31

4 (36.36)

APOA1, FGG, HRG, TF

8.29e-3

 

Cytoplasmic vesicle

2.31

4 (36.36)

APOA1, FGG, HRG, TF

1.16e-2

  1. +The classification stringency was set to high.