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Table 4 Haplotype frequencies of miR-146a C > G, miR-149 T > C, miR-196a2 T > C and miR-499 T > C SNPs in the Southern Han population

From: Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations

Haplotype

Allele at marker

Controls N (Freq)

Patients N (Freq)

Total N (Freq)

OR (95% CI)

Pvalue

miR-499

miR-196a2

miR-146a

miR-149

1

T

C

C

T

0.1639

0.1699

0.1643

1.00

---

2

T

T

G

T

0.1491

0.1689

0.1487

0.96 (0.51 - 1.79)

0.9

3

T

T

C

T

0.1266

0.136

0.1378

0.67 (0.27 - 1.65)

0.38

4

T

T

C

C

0.0662

0.1378

0.0953

2.33 (0.98 - 5.55)

0.057

5

T

T

G

C

0.0761

0.0697

0.0828

0.60 (0.24 - 1.50)

0.27

6

T

C

G

T

0.0926

0.0533

0.0796

0.35 (0.10 - 1.19)

0.092

7

T

C

G

C

0.0711

0.0736

0.0652

0.95 (0.38 - 2.36)

0.91

8

T

C

C

C

0.0607

0.0358

0.053

0.23 (0.05 - 0.96)

0.044

9

C

T

G

T

0.0384

0.0174

0.0366

0.24 (0.04 - 1.37)

0.11

10

C

C

C

T

0.0325

0.0065

0.0303

0.03 (0.01 - 0.63)

0.024

11

C

T

C

T

0.0182

0.0365

0.0211

3.38 (0.54 - 21.22)

0.19

12

C

C

C

C

0.0333

0.0188

0.0194

0.42 (0.04 - 4.04)

0.45

13

C

C

G

C

0

0.0244

0.0189

0.00 (-Inf - Inf)

1

14

C

T

G

C

0.0457

0

0.0181

0.00 (-Inf - Inf)

1

15

C

T

C

C

0.0052

0.017

0.0158

1.41 (0.02 - 90.56)

0.87

16

C

C

G

T

0.0203

0.0344

0.0131

1.35 (0.19 - 9.60)

0.76

Global haplotype association P-value: 0.0084

  1. Freq: frequency of haplotype, OR: odds ratio, N: number of subjects, CI: confidence interval.