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Table 3 Allele frequencies and genotype distributions of miR-146a C > G, miR-149 T > C, miR-196a2 T > C and miR-499 T > C SNPs in the Chinese Kazak population

From: Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations

SNP sites Controls N (Freq) Patients N (Freq) Pvalue OR (95% CI)
miR-146a C > G Allele G 422(0.598) 284(0.402) 0.023 1 1.33(1.04-1.69)
C 222(0.529) 198(0.171)
Genotype GG 124(0.351) 65(0.310)   1
GC 174(0.493) 92(0.438) 0.965 1.01(0.68-1.49)
CC 55(0.156) 53(0.252) 0.013 1.84(1.14-2.98)
  HWE(P) 0.637 0.080   
miR-149 T > C Allele T 437(0.604) 189(0.580) 0.466 1 1.10(0.84-1.44)
C 287(0.396) 137(0.420)
Genotype TT 131(0.362) 52(0.319)   1
TC 175(0.483) 85(0.521) 0.338 1.22 (0.81-1.85)
CC 56(0.155) 26(0.160) 0.587 1.17 (0.66-2.06)
  HWE(P) 0.845904 0.370294   
miR-196a2 T > C Allele C 378(0.549) 314(0.625) 0.008 1 0.73(0.58-0.92)
T 310(0.451) 188(0.451)
Genotype CC 103(0.299) 99(0.394)   1
TC 172(0.500) 116(0.462) 0.055 0.72(0.49-1.01)
TT 69(0.201) 36(0.143) 0.013 0.54(0.33-0.88)
  HWE(P) 0.855 0.830   
miR-499 T > C Allele T 382(0.813) 285(0.828) 0.565 10.90(0.62-1.29)
C 88(0.187) 59(0.172)
Genotype TT 157(0.668) 116(0.674)   1
TC 68(0.298) 53(0.308) 0.808 1.06(0.68-1.62)
CC 10(0.043) 3(0.017) 0.165 0.41(0.11-1.51)
  HWE(P) 0.450 0.269   
  1. SNP: single nucleotide polymorphism, HWE: Hardy-Weinberg equilibrium, OR: odds ratio, CI: confidence interval, N: number of alleles, Freq: frequency. All of the miRNA SNPs were in HWE.