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Table 2 Allele frequencies and genotype distributions of miR-146a C > G, miR-149 T > C, miR-196a2 T > C and miR-499 T > C SNPs in the Chinese Uygur population

From: Association of the miR-146a, miR-149, miR-196a2 and miR-499 polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese Uygur, Kazak and Southern Han populations

SNP sites Controls N (Freq) Patients N (Freq) Pvalue OR (95% CI)
miR-146a C > G Allele G 441(0.611) 358(0.622) 0.693 1 0.96(0.76-1.20)
C 281(0.389) 218(0.378)
Genotype GG 131(0.368) 106(0.368)   1
GC 179(0.496) 146(0.507) 0.963 1.00(0.72-1.41)
CC 51(0.141) 36(0.125) 0.591 0.87(0.53-1.43)
  HWE(P) 0.415 0.188   
miR-149 T > C Allele C 342(0.521) 274(0.511) 0.727 1 1.04(0.83-1.31)
T 314(0.479) 262(0.489)
Genotype CC 89(0.271) 75(0.280)   1
TC 164(0.500) 124(0.164) 0.581 0.89(0.61-1.32)
TT 75(0.229) 69(0.257) 0.701 1.09(0.69-1.71)
  HWE(P) 0.974 0.225   
miR-196a2 T > C Allele C 378(0.531) 286(0.498) 0.244 1 1.14(0.91-1.42)
T 334(0.469) 288(0.502)
Genotype CC 96(0.270) 67(0.233)   1
TC 186(0.522) 152(0.530) 0.414 1.17(0.80-1.71)
TT 74(0.208) 68(0.237) 0.234 1.32(0.84-2.07)
  HWE(P) 0.356 0.316   
miR-499 T > C Allele T 421(0.829) 455(0.756) 0.003 1 1.56(1.16-2.10)
C 87(0.171) 147(0.244)
Genotype TT 171(0.673) 176(0.585)   1
TC 79(0.311) 103(0.342) 0.199 1.27(0.88-1.82)
CC 4(0.016) 22(0.073) 0.001 5.34(1.80-15.83)
  HWE(P) 0.127 0.205   
  1. SNP: single nucleotide polymorphism, HWE: Hardy-Weinberg equilibrium, OR: odds ratio, CI: confidence interval, N: number of alleles, Freq: frequency. All of the miRNA SNPs were in HWE.