From: A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections
Group
Dose
Mean (min – max) Faecal concentrations (μg/g)
Nominal day of dosing
Day 5
Day 10
G
200 mg twice daily
1,466 (847 – 2,390)
1,364 (783 – 1,980)
H
500 mg twice daily
2,084 (994 – 3,790)
3,318 (2,130 – 4,970)