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Table 5 Faecal concentrations of SMT19969 following multiple oral doses (Part 2)

From: A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections

Group

Dose

Mean (min – max) Faecal concentrations (μg/g)

Nominal day of dosing

Day 5

Day 10

G

200 mg twice daily

1,466 (847 – 2,390)

1,364 (783 – 1,980)

H

500 mg twice daily

2,084 (994 – 3,790)

3,318 (2,130 – 4,970)