Table 4 Seroconversion rates and geometric mean titers after vaccination compared to before vaccination (per-protocol population, homologous response)
Time point | Value | KD-287 (n = 93) | JEV-GCC (n = 95) | *Difference/Ratio | |
|---|---|---|---|---|---|
SCR | Seropositive at baseline | n (%) | 0 (0.0) | 1 (1.0) | |
95% CI | |||||
After 2nd dose | n (%) | 93 (100.0) | 93 (97.9) | 2.1 | |
95% CI | (−0.78, 4.99) | ||||
Before 3rd dose | n (%) | 93 (100.0) | 90 (94.7) | 5.3 | |
95% CI | (0.77, 9.75) | ||||
After 3rd dose | n (%) | 93 (100.0) | 94 (98.9) | 1.1 | |
95% CI | (100.0, 100.0) | (96.9, 100.0) | (−1.00, 3.10) | ||
GMT | Before Vaccination | log10n | 5 | 5 | 1.0 |
95% CI | (5, 6) | (1.0, 1.1) | |||
After 2nd dose | log10n | 601 | 107 | 5.6† | |
95% CI | (509, 709) | (84, 137) | (4.2, 7.5) | ||
Before 3rd dose | log10n | 917 | 45 | 20.1† | |
95% CI | (757, 1110) | (36, 56) | (15.2, 26.7) | ||
After 3rd dose | log10n | 13347 | 967 | 13.8† | |
95% CI | (11455, 15551) | (798, 1172) | (10.8, 17.6) |