Age-adjusted case-fatality rates of Severe Sepsis from 2006 to 2011. Changes with time in case-fatality rate (CRF) by 100 episodes of severe sepsis. Overall rate (solid line), data in men (long-dash), data in women (short-dash). Age- and sex- standardised CFR showed a significant decrease over time going from 49.3 per 100 in 2006 to 41.9 in 2011. In men, the standardised rate has gone from 48.71 cases per 100 in 2006 to 40.97 cases/100 in 2011 whereas in women the rate has gone from 50.34 cases/100 in 2006 to 43.22 cases/100 in 2011.