Number of cases and age-adjusted national incidence of severe sepsis in Spain from 2006 to 2011. The data correspond to the annual number of cases (plot 1a) and the age-adjusted standardized incidence rates (plot 1b) for the whole population of severe sepsis and for men and women in a specific manner. Rates were calculated by direct methods based on the European standard population. For the entire population, cases raised from 28579 in 2006 to 49782 in 2011. The standardised rate increased from 70.86 in 2006 to 112.11 cases/100000 population in 2011. In men (central section), cases have gone from 16927 in 2006 to 28488 in 2011. The standardised rate has increased from 95.02 cases/100000 population in 2006 to 147.05 cases/100000 population in 2011. In women, cases have gone from 11651 to 21293 and the standardised incidence rate has increased from 51.73 cases/100000 population in 2006 to 84.57 cases/100000 population in 2011.