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Table 4 Interaction analysis between favorable SNPs and selected risk factors

From: Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study

a) Combined favorable alleles (rs1063478-T and rs2284191-G) and history of plasma donation
Variables Uninfected N(%) Infected N(%) OR (95% CI)
0-2 favorable alleles with plasma donation 184 (40.7) 421 (58.1) 1.00
3-4 favorable alleles with plasma donation 154 (34.1) 261 (36.0) 0.66 (0.49-0.89)
0-2 favorable alleles without plasma donation 80 (17.7) 18 (2.5) 0.16 (0.08-0.30)
3-4 favorable alleles without plasma donation 64 (7.5) 25 (3.4) 0.18 (0.10-0.32)
P for multiplicative interaction    P = 0.020
b) rs7383287 genotypes and history of blood donation
Variables Resolver N(%) Chronic N(%) OR (95% CI)
AA genotypes with blood donation 115 (59.6) 349 (65.6) 1.00
AG/GG genotypes with blood donation 10 (5.2) 42 (7.9) 1.39 (0.64-2.99)
AA genotypes without blood donation 55 (28.5) 127 (23.9) 0.76 (0.51-1.13)
AG/GG genotypes without blood donation 13 (6.7) 14 (2.6) 0.34 (0.15-0.78)
P for multiplicative interaction    P = 0.040
  1. Logistic regression analyses adjusted for age, gender, experience of blood/plasma donation, and numbers of blood/plasma donation.