Skip to main content

Table 3 Cumulative effects of selected SNPs on HCV infection outcomes

From: Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study

a) Combined favorable alleles (rs1063478–T and rs2284191–G) and anti–HCV
Variables Uninfected N(%) Infected N(%) OR (95% CI)
0–1 37 (7.7) 75 (10.0) 1.00
2 227 (47.1) 364 (48.4) 0.62 (0.37–1.03)
3 188 (39.0) 245 (32.6) 0.46 (0.27–0.78)
4 30 (6.2) 41 (9.0) 0.50 (0.24–1.04)
Trend    P a = 0.037
0–2 264 (54.8) 439 (58.4) 1.00
3–4 218 (45.2) 286 (41.6) 0.70 (0.53–0.93)
b) Combined favorable alleles (rs17587–A and rs7383287–G) and HCV chronicity
Variables Resolver N(%) Chronic N(%) OR (95% CI)
0 71 (36.8) 257 (48.3) 1.00
1 62 (32.1) 177 (33.3) 0.79 (0.53–1.77)
2 50 (25.9) 74 (13.9) 0.42 (0.26–0.66)
3–4 10 (5.2) 23 (4.5) 0.62 (0.27–1.37)
Trend    P a = 0.001
0 71 (36.8) 257 (48.3) 1.00
1–4 122 (63.2) 275 (51.7) 0.63 (0.45–0.88)
  1. Logistic regression analyses adjusted for age, gender, experience of blood/plasma donation, and numbers of blood/plasma donation.
  2. a P value of Cochran-Armitage’s trend test.