Table 2 Association of selected SNPs with HCV infection outcomes
a) SNPs associated with anti-HCV status | ||||
|---|---|---|---|---|
Genotype | Uninfected N(%) | Infected N(%) | OR (95% CI) | P value |
rs1063478 | ||||
CC | 223 (46.3%) | 373 (51.4%) | 1.00 | |
CT | 216 (44.8%) | 297 (41.0%) | 0.75 (0.56–0.99) | 0.049 |
TT | 43 (8.9%) | 55 (7.6%) | 0.72 (0.43–1.20) | 0.210 |
Dominant | 0.74 (0.56–0.98) | 0.035 | ||
Recessive | 0.83 (0.50–1.35) | 0.444 | ||
Additive | 0.81 (0.65–0.99) | 0.049 | ||
rs2284191 | ||||
GG | 395 (82.0%) | 572 (78.9%) | 1.00 | |
AG | 81 (16.8%) | 146 (20.1%) | 1.45 (1.01–2.07) | 0.430 |
AA | 6 (1.2%) | 7 (1.0%) | 1.32 (0.32–5.83) | 0.701 |
Dominant | 1.44 (1.01–2.05) | 0.041 | ||
Recessive | 1.23 (0.30–5.00) | 0.772 | ||
Additive | 1.38 (1.00–1.92) | 0.050 | ||
rs11244 | ||||
CC | 288 (62.4%) | 430 (63.1%) | 1.00 | |
CT | 147 (31.8%) | 211 (21.6%) | 1.14 (0.83–1.55) | 0.416 |
TT | 27 (5.8%) | 40 (5.9%) | 1.97 (1.06–3.65) | 0.033 |
Dominant | 1.12 (0.84–1.50) | 0.426 | ||
Recessive | 1.74 (0.95–3.18) | 0.073 | ||
Additive | 1.26 (1.00–1.60) | 0.053 | ||
b) SNPs associated with HCV chronicity | ||||
Genotype | Resolver N(%) | Chronic N(%) | OR (95% CI) | P value |
rs17587 | ||||
GG | 123 (63.7%) | 361 (67.9%) | 1.00 | |
AG | 58 (30.1%) | 158 (29.8%) | 0.94 (0.65–136) | 0.745 |
AA | 12 (6.2%) | 12 (2.3%) | 0.32 (0.14–0.75) | 0.009 |
Dominant | 0.83 (0.58–1.18) | 0.303 | ||
Recessive | 0.33 (0.14–0.76) | 0.009 | ||
Additive | 0.76 (0.57–1.03) | 0.077 | ||
rs2071543 | ||||
CC | 125 (64.7%) | 356 (66.9%) | 1.00 | |
AC | 54 (28.0%) | 157 (29.5%) | 1.06 (0.73–1.55) | 0.756 |
AA | 14 (7.3%) | 19 (3.6%) | 0.49 (0.24–1.02) | 0.058 |
Dominant | 0.94 (0.66–1.34) | 0.749 | ||
Recessive | 0.48 (0.24–0.99) | 0.049 | ||
Additive | 0.86 (0.65–1.15) | 0.318 | ||
rs2284191 | ||||
GG | 142 (73.6%) | 430 (80.3%) | 1.00 | |
AG | 50 (25.9%) | 96 (18.1%) | 0.59 (0.40, 0.88) | 0.010 |
AA | 1 (0.5%) | 6 (1.1%) | 1.41 (0.15, 12.89) | 0.760 |
Genotype | Resolver N(%) | Chronic N(%) | OR (95% CI) | P value |
Dominant | 0.61 (0.41, 0.90) | 0.014 | ||
Recessive | 1.59 (0.17, 14.43) | 0.683 | ||
Additive | 0.65 (0.45, 0.95) | 0.240 | ||
rs376892 | ||||
CC | 109 (56.5%) | 321 (60.3%) | 1.00 | |
CT | 81 (42.0%) | 183 (34.4%) | 0.67 (0.54–1.07) | 0.112 |
TT | 3 (1.5%) | 28 (5.3%) | 3.15 (0.93–10.64) | 0.065 |
Dominant | 0.84 (0.60–1.18) | 0.317 | ||
Recessive | 3.51 (1.04–11.77) | 0.042 | ||
Additive | 0.98 (0.74–1.32) | 0.918 | ||
rs416622 | ||||
GG | 66 (34.2%) | 242 (45.5%) | 1.00 | |
AG | 105 (54.4%) | 216 (40.6%) | 0.51 (0.35–0.74) | <0.001 |
AA | 22 (11.4%) | 74 (13.9%) | 0.91 (0.52–1.59) | 0.739 |
Dominant | 0.58 (0.41–0.83) | 0.003 | ||
Recessive | 1.31 (0.78–2.19) | 0.300 | ||
Additive | 0.82 (0.64–1.04) | 0.102 | ||
rs7383287 | ||||
AA | 125 (64.8%) | 391 (73.5%) | 1.00 | |
AG | 25 (13.0%) | 67 (12.6%) | 0.84 (0.50–1.39) | 0.495 |
GG | 43 (22.2%) | 74 (13.9%) | 0.54 (0.35–0.85) | 0.008 |
Dominant | 0.66 (0.46–0.95) | 0.025 | ||
Recessive | 0.56 (0.36–0.87) | 0.001 | ||
Additive | 0.75 (0.60–0.93) | 0.001 | ||