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Table 2 Association of selected SNPs with HCV infection outcomes

From: Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study

a) SNPs associated with anti-HCV status
Genotype Uninfected N(%) Infected N(%) OR (95% CI) P value
rs1063478     
CC 223 (46.3%) 373 (51.4%) 1.00  
CT 216 (44.8%) 297 (41.0%) 0.75 (0.56–0.99) 0.049
TT 43 (8.9%) 55 (7.6%) 0.72 (0.43–1.20) 0.210
Dominant    0.74 (0.56–0.98) 0.035
Recessive    0.83 (0.50–1.35) 0.444
Additive    0.81 (0.65–0.99) 0.049
rs2284191     
GG 395 (82.0%) 572 (78.9%) 1.00  
AG 81 (16.8%) 146 (20.1%) 1.45 (1.01–2.07) 0.430
AA 6 (1.2%) 7 (1.0%) 1.32 (0.32–5.83) 0.701
Dominant    1.44 (1.01–2.05) 0.041
Recessive    1.23 (0.30–5.00) 0.772
Additive    1.38 (1.00–1.92) 0.050
rs11244     
CC 288 (62.4%) 430 (63.1%) 1.00  
CT 147 (31.8%) 211 (21.6%) 1.14 (0.83–1.55) 0.416
TT 27 (5.8%) 40 (5.9%) 1.97 (1.06–3.65) 0.033
Dominant    1.12 (0.84–1.50) 0.426
Recessive    1.74 (0.95–3.18) 0.073
Additive    1.26 (1.00–1.60) 0.053
b) SNPs associated with HCV chronicity
Genotype Resolver N(%) Chronic N(%) OR (95% CI) P value
rs17587     
GG 123 (63.7%) 361 (67.9%) 1.00  
AG 58 (30.1%) 158 (29.8%) 0.94 (0.65–136) 0.745
AA 12 (6.2%) 12 (2.3%) 0.32 (0.14–0.75) 0.009
Dominant    0.83 (0.58–1.18) 0.303
Recessive    0.33 (0.14–0.76) 0.009
Additive    0.76 (0.57–1.03) 0.077
rs2071543     
CC 125 (64.7%) 356 (66.9%) 1.00  
AC 54 (28.0%) 157 (29.5%) 1.06 (0.73–1.55) 0.756
AA 14 (7.3%) 19 (3.6%) 0.49 (0.24–1.02) 0.058
Dominant    0.94 (0.66–1.34) 0.749
Recessive    0.48 (0.24–0.99) 0.049
Additive    0.86 (0.65–1.15) 0.318
rs2284191     
GG 142 (73.6%) 430 (80.3%) 1.00  
AG 50 (25.9%) 96 (18.1%) 0.59 (0.40, 0.88) 0.010
AA 1 (0.5%) 6 (1.1%) 1.41 (0.15, 12.89) 0.760
Genotype Resolver N(%) Chronic N(%) OR (95% CI) P value
Dominant    0.61 (0.41, 0.90) 0.014
Recessive    1.59 (0.17, 14.43) 0.683
Additive    0.65 (0.45, 0.95) 0.240
rs376892     
CC 109 (56.5%) 321 (60.3%) 1.00  
CT 81 (42.0%) 183 (34.4%) 0.67 (0.54–1.07) 0.112
TT 3 (1.5%) 28 (5.3%) 3.15 (0.93–10.64) 0.065
Dominant    0.84 (0.60–1.18) 0.317
Recessive    3.51 (1.04–11.77) 0.042
Additive    0.98 (0.74–1.32) 0.918
rs416622     
GG 66 (34.2%) 242 (45.5%) 1.00  
AG 105 (54.4%) 216 (40.6%) 0.51 (0.35–0.74) <0.001
AA 22 (11.4%) 74 (13.9%) 0.91 (0.52–1.59) 0.739
Dominant    0.58 (0.41–0.83) 0.003
Recessive    1.31 (0.78–2.19) 0.300
Additive    0.82 (0.64–1.04) 0.102
rs7383287     
AA 125 (64.8%) 391 (73.5%) 1.00  
AG 25 (13.0%) 67 (12.6%) 0.84 (0.50–1.39) 0.495
GG 43 (22.2%) 74 (13.9%) 0.54 (0.35–0.85) 0.008
Dominant    0.66 (0.46–0.95) 0.025
Recessive    0.56 (0.36–0.87) 0.001
Additive    0.75 (0.60–0.93) 0.001
  1. Logistic regression analyses adjusted for age, gender, experience of blood/plasma donation, and numbers of blood/plasma donation.