From: HIV treatment outcomes among people who inject drugs in Victoria, Australia
AIDS | Death | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | ||||||||||
HR | CI 95 | P | HR | CI 95 | P | HR | CI 95 | P | HR | CI 95 | P | ||
Risk group | Non injecting drug use | Ref | Ref | Ref | Ref | ||||||||
Injecting drug use | 0.70 | 0.39 -1.27 | 0.242 | 0.98 | 0.54 - 1.79 | 0.944 | 0.49 | 0.12 - 2.04 | 0.328 | 0.76 | 0.17 - 3.3 | 0.709 | |
Heterosexual | Ref | Ref | Ref | Ref | |||||||||
MSM | 1.24 | 0.83 -1.86 | 0.299 | 1.07 | 0.7 - 1.63 | 0.750 | 1.81 | 0.71 - 4.59 | 0.215 | 1.28 | 0.48 - 3.42 | 0.625 | |
Age at diagnosis (years) | < 25 | Ref | Ref | Ref | Ref | ||||||||
25 - 34 | 1.04 | 0.68 – 1.58 | 0.872 | 1.81 | 1.04 - 3.15 | 0.035* | 0.84 | 0.37 – 1.90 | 0.677 | 1.11 | 0.39 - 3.12 | 0.850 | |
35+ | 1.34 | 0.88 – 2.04 | 0.170 | 3.59 | 1.88 - 6.85 | 0.000*** | 1.14 | 0.59 – 2.53 | 0.737 | 3.34 | 0.93 - 12.02 | 0.065 | |
Age at contact with treatment service (years) | < 25 | Ref | Ref | Ref | Ref | ||||||||
25 - 34 | 0.87 | 0.47 – 1.58 | 0.639 | 0.46 | 0.21 - 0.98 | 0.045* | 0.98 | 0.28 – 3.37 | 0.969 | 0.55 | 0.12 - 2.49 | 0.441 | |
35+ | 0.88 | 0.49 – 1.57 | 0.661 | 0.22 | 0.1 - 0.51 | 0.000*** | 0.91 | 0.28 – 3.02 | 0.881 | 0.22 | 0.04 - 1.17 | 0.075 | |
Initial CD4 count (cells/mm 3 ) | <200 | Ref | Ref | Ref | Ref | ||||||||
200 - 349 | 0.18 | 0.11 -0.30 | 0.000*** | 0.18 | 0.11 - 0.3 | 0.000*** | 0.39 | 0.17 - 0.89 | 0.025* | 0.54 | 0.22 - 1.3 | 0.167 | |
350 - 499 | 0.21 | 0.13 -0.34 | 0.000*** | 0.21 | 0.13 - 0.34 | 0.000*** | 0.31 | 0.12 - 0.80 | 0.015* | 0.43 | 0.16 - 1.17 | 0.100 | |
500+ | 0.19 | 0.12 -0.29 | 0.000*** | 0.20 | 0.13 - 0.32 | 0.000*** | 0.17 | 0.06 - 0.49 | 0.001*** | 0.30 | 0.1 - 0.93 | 0.038* | |
Ever CD4 (cells/mm 3 ) | < 200 § | 3.06 | 2.05 -4.56 | 0.000*** | 3.61 | 2.25 – 5.82 | 0.000*** | 9.41 | 5.19 - 17.04 | 0.000*** | 9.00 | 4.04 – 20.02 | 0.000*** |
Ever CD4 (cells/mm 3 ) | > 500 § | 0.32 | 0.24 -0.43 | 0.000*** | 0.30 | 0.21 – 0.41 | 0.000*** | 0.09 | 0.04 - 0.19 | 0.000*** | 0.08 | 0.04 - 0.19 | 0.000*** |
Initial viral load (log 10 copies) | < 4 log | Ref | Ref | Ref | Ref | ||||||||
4 - 4.99 log | 1.23 | 0.83 -1.84 | 0.307 | 1.11 | 0.73 - 1.67 | 0.632 | 0.71 | 0.31 - 1.63 | 0.422 | 0.57 | 0.24 - 1.36 | 0.208 | |
5 + log | 2.60 | 1.80 -3.77 | 0.000*** | 1.77 | 1.18 - 2.65 | 0.005** | 1.86 | 0.94 - 3.67 | 0.075 | 1.76 | 0.81 - 3.85 | 0.154 | |
Year of diagnosis | < 1996 | Ref | Ref | ||||||||||
1996 - 1999 | 1.45 | 1.00 -2.10 | 0.052 | 1.65 | 0.83 - 3.27 | 0.155 | |||||||
2000 - 2002 | 1.68 | 1.07 -2.65 | 0.025* | 0.66 | 0.21 - 2.05 | 0.471 | |||||||
2003 - 2005 | 1.71 | 1.00 -2.94 | 0.050* | 1.14 | 0.35 - 3.65 | 0.829 | |||||||
Year of commencement ART | < 1996 | Ref | Ref | ||||||||||
1996 – 1999 | 0.53 | 0.16 -1.72 | 0.288 | Ref | . | 0.58 | 0.14 - 2.52 | 0.471 | Ref | . | |||
2000 - 2002 | 0.30 | 0.09 -0.99 | 0.048* | 0.58 | 0.35 - 0.97 | 0.036* | 0.23 | 0.05 - 1.01 | 0.051 | 0.34 | 0.16 - 0.73 | 0.006** | |
2003 – 2005 | 0.29 | 0.09 -0.92 | 0.036* | 0.64 | 0.4 - 1.02 | 0.062 | 0.11 | 0.03 - 0.52 | 0.005** | 0.19 | 0.08 - 0.42 | 0.000*** | |
2006 - 2008 | 0.31 | 0.10 -1.01 | 0.051 | 0.57 | 0.36 - 0.9 | 0.017* | 0.01 | 0.00 - 0.09 | 0.000*** | 0.01 | 0 - 0.08 | 0.000*** |