Table 2 Adjusted hazard ratios and 95% confidence intervals as estimated by Cox proportional hazards regression for second-line cART failure stratified by HIV RNA level at time of second-line cART initiation, 2000-2013
| Â | Â | Undetectable | Detectable |
|---|---|---|---|
Age | Â | Â | Â |
| Â | <30Â years | Ref. | Ref. |
| Â | 30-39 years | 0.75 (0.34-1.70) | 0.54 (0.35-0.83) |
|  | ≥40 years | 0.44 (0.22-0.90) | 0.58 (0.38-0.89) |
Education | Â | Â | Â |
| Â | >8Â years | Â | Ref. |
|  | ≤8 years |  | 1.44 (1.01-2.03) |
HIV RNA level, copies/ml | Â | Â | |
| Â | 401-10,000 | Â | Ref. |
| Â | 10,001-100,000 | Â | 1.42 (0.98-2.06) |
| Â | >100,000 | Â | 1.09 (0.70-1.70) |
Second-line cART anchor agent | Â | Â | |
| Â | NNRTI-PI/r | Ref. | Â |
| Â | NNRTI-PI | 1.19 (0.53-2.70) | Â |
| Â | PI/PI/r-NNRTI | 0.40 (0.18-0.85) | Â |
| Â | PI/PI/r-PI/PI-r | 0.39 (0.15-0.96) | Â |
Time from first-line to second-line initiation | Â | Â | |
| Â | Per 1Â month increase | 0.97 (0.95-0.99) | Â |