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Table 4 Case fatality, mortality rate and risk of death by month since starting TB treatment for retreatment TB episodes, by HIV status

From: Timing, rates, and causes of death in a large South African tuberculosis programme

HIV/ART status Time on treatment 1 n Number of deaths Cumulative case fatality (%) Person months Rate per 100 pm (95% CI) IRR (95% CI) p-value for trend
         0.06
HIV negative or unknown 1st month 217 2 0.9 216 0.9 (0.2-3.7) 1.0  
2nd month 215 2 1.8 213 0.9 (0.2-3.7) 1.01 (0.14-7.18)  
3rd-6th month 213 4 3.7 844 0.5 (0.2-1.3) 0.51 (0.09-2.79)  
7th-8th month 209 0 3.7 418 0.0 --  
Overall 217 8 3.7 1691 0.5 (0.2-0.9)   
         <0.01
HIV positive on ART 1st month 277 14 5.1 270 5.2 (3.1-8.8) 1.0  
2nd month 263 7 7.6 259 2.7 (1.3-5.7) 0.52 (0.21-1.29)  
3rd-6th month 256 31 18.8 951 3.3 (2.3-4.6) 0.63 (0.33-1.18)  
7th-8th month 225 9 22.0 439 2.1 (1.1-3.9) 0.39 (0.17-0.91)  
Overall 277 61 22.0 1919 3.2 (2.5-4.1)   
         0.03
HIV positive not on ART 1st month 498 30 6.0 482 6.2 (4.4-8.9) 1.0  
2nd month 468 19 9.8 461 4.1 (2.6-6.5) 0.66 (0.37-1.18)  
3rd-6th month 449 66 23.1 1639 4.0 (3.2-5.1) 0.65 (0.42-1.00)  
7th-8th month 383 17 26.5 744 2.3 (1.4-3.7) 0.37 (0.20-0.66)  
Overall 498 132 26.5 3325 4.0 (3.3-4.7)   
  1. 1Months 3–6 and 7–8 were grouped because mortality rates were observed to be stable during these time periods and the numbers of deaths were small.