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Table 2 Case fatality, mortality rate and risk of death by month since starting TB treatment, by first and retreatment TB episodes

From: Timing, rates, and causes of death in a large South African tuberculosis programme

 

Time on treatment

n

Number of deaths

Cumulative case fatality (%)

Person months

Rate per 100 pm (95% CI)

IRR (95% CI)

p -value

First episode

1st month

3170

71

2.2

3132

2.3 (1.8-2.9)

1.0

 

2nd month

3099

50

3.8

3072

1.6 (1.2-2.1)

0.72 (0.50-1.0)

0.07

3rd month

3049

47

5.3

3023

1.6 (1.2-2.1)

0.69 (0.47-0.99)

0.05

4th month

3002

46

6.8

2979

1.5 (1.2-2.1)

0.68 (0.47-0.99)

0.04

5th month

2956

44

8.1

2936

1.5 (1.1-2.0)

0.66 (0.45-0.96)

0.03

6th month

2912

50

9.7

2889

1.7 (1.3-2.3)

0.76 (0.53-1.10)

0.14

Overall

3170

308

9.7

18030

1.7 (1.5-1.9)

  

Retreatment episode

1st month

992

46

4.6

967

4.8 (3.6-6.4)

1.0

 

2nd month

946

28

7.5

933

3.0 (2.1-4.3)

0.63 (0.39-1.01)

0.05

3rd month

918

34

10.9

898

3.8 (2.7-5.3)

0.80 (0.51-1.24)

0.31

4th month

884

32

14.1

865

3.7 (2.6-5.2)

0.78 (0.50-1.22)

0.28

5th month

852

19

16.0

844

2.3 (1.4-3.5)

0.47 (0.28-0.81)

0.01

6th month

833

16

17.6

827

1.9 (1.2-3.2)

0.41 (0.23-0.72)

<0.01

7th month

817

17

19.4

808

2.1 (1.3-3.4)

0.44 (0.25-0.77)

<0.01

8th month

800

9

20.3

793

1.1 (0.6-2.2)

0.24 (0.12-0.49)

<0.01

Overall

992

201

20.3

6935

2.9 (2.5-3.3)

  

Overall

4162

509

12.2

24965

2.0 (1.9-2.2)

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