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Table 2 Case fatality, mortality rate and risk of death by month since starting TB treatment, by first and retreatment TB episodes

From: Timing, rates, and causes of death in a large South African tuberculosis programme

  Time on treatment n Number of deaths Cumulative case fatality (%) Person months Rate per 100 pm (95% CI) IRR (95% CI) p -value
First episode 1st month 3170 71 2.2 3132 2.3 (1.8-2.9) 1.0  
2nd month 3099 50 3.8 3072 1.6 (1.2-2.1) 0.72 (0.50-1.0) 0.07
3rd month 3049 47 5.3 3023 1.6 (1.2-2.1) 0.69 (0.47-0.99) 0.05
4th month 3002 46 6.8 2979 1.5 (1.2-2.1) 0.68 (0.47-0.99) 0.04
5th month 2956 44 8.1 2936 1.5 (1.1-2.0) 0.66 (0.45-0.96) 0.03
6th month 2912 50 9.7 2889 1.7 (1.3-2.3) 0.76 (0.53-1.10) 0.14
Overall 3170 308 9.7 18030 1.7 (1.5-1.9)   
Retreatment episode 1st month 992 46 4.6 967 4.8 (3.6-6.4) 1.0  
2nd month 946 28 7.5 933 3.0 (2.1-4.3) 0.63 (0.39-1.01) 0.05
3rd month 918 34 10.9 898 3.8 (2.7-5.3) 0.80 (0.51-1.24) 0.31
4th month 884 32 14.1 865 3.7 (2.6-5.2) 0.78 (0.50-1.22) 0.28
5th month 852 19 16.0 844 2.3 (1.4-3.5) 0.47 (0.28-0.81) 0.01
6th month 833 16 17.6 827 1.9 (1.2-3.2) 0.41 (0.23-0.72) <0.01
7th month 817 17 19.4 808 2.1 (1.3-3.4) 0.44 (0.25-0.77) <0.01
8th month 800 9 20.3 793 1.1 (0.6-2.2) 0.24 (0.12-0.49) <0.01
Overall 992 201 20.3 6935 2.9 (2.5-3.3)   
Overall 4162 509 12.2 24965 2.0 (1.9-2.2)