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Table 3 Odds ratios for HPV18 seropositivity in women with normal cytology

From: Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study

Characteristic Anti-HPV18 Atb a Unadjusted OR (95% CI) OR1 b(95% CI) OR2 c(95% CI) p-trend/p-nominal d
-ve +ve
All women 3053 128     
Age
 30-39 510 22 Ref. n/a Ref.  
 40-49 421 17 0.94 (0.49-1.79) n/a 0.92 (0.48-1.78) 0.893
 50-59 1651 77 1.08 (0.67-1.79) n/a 1.23 (0.74-2.03) 0.378
 60-64 471 12 0.59 (0.29-1.21) n/a 0.76 (0.36-1.59)  
Smoking
 Never 1809 58 Ref. Ref. Ref.  
 Past 928 59 1.98 (1.37-2.88) 1.99 (1.37-2.89) 1.40 (0.94-2.07) n/ae
 Current 316 11 1.09 (0.56-2.09) 1.07 (0.56-2.07) 0.70 (0.36-1.39) 0.065
N o of children
 0 311 15 Ref. Ref. Ref.  
 1 359 18 1.04 (0.51-2.10) 1.06 (0.52-2.14) 1.13 (0.55-2.34) 0.352
 2 1229 62 1.04 (0.59-1.86) 1.06 (0.59-1.89) 1.39 (0.75-2.55) 0.174
≥3 1154 33 0.59 (0.32-1.10) 0.60 (0.32-1.13) 0.86 (0.44-1.66)  
Age at sexual debut
≥18 1800 64 Ref. Ref. Ref.  
 17 463 23 1.40 (0.86-2.27) 1.35 (0.83-2.20) 0.99 (0.60-1.64) 0.941
 16 428 24 1.58 (0.97-2.55) 1.53 (0.94-2.48) 1.02 (0.61-1.71) 0.605
 15 171 6 0.99 (0.42-2.31) 0.96 (0.41-2.25) 0.63 (0.26-1.52)  
 <15 108 8 2.08 (0.97-4.46) 2.02 (0.94-4.34) 1.25 (0.56-2.78)  
 Prefer not to answer 83 3 1.02 (0.31-3.30) 1.01 (0.31-3.28) 0.39 (0.11-1.42)  
C. trachomatis diagnosis
 No 2898 114 Ref. Ref. Ref.  
 Yes 123 10 2.07 (1.06-4.05) 2.02 (1.03-3.97) 1.58 (0.79-3.17) n/ae
 Prefer not to answer 32 4 3.18 (1.11-9.14) 3.15 (1.09-9.09) 2.16 (0.71-6.55) 0.187
Partners in last 5y
 0-1 2770 114 Ref. Ref. Ref.  
 2 129 5 0.94 (0.38-2.35) 0.92 (0.37-2.29) 0.73 (0.29-1.85) 0.939
 ≥3 107 8 1.82 (0.86-3.82) 1.83 (0.86-3.92) 1.34 (0.61-2.95) 0.499
 Prefer not to answer 47 1 0.52 (0.07-3.78) 0.52 (0.07-3.82) 0.30 (0.04-2.36)  
Partners before the last 5y
 0-1 1295 19 Ref. Ref. Ref.  
 2 280 14 3.42 (1.70-6.91) 3.32 (1.64-6.70) 3.14 (1.55-6.39) 0.032
 ≥3 1189 70 4.07 (2.44-6.80) 3.95 (2.35-6.61) 3.49 (2.00-6.06) <0.001
 Prefer not to answer 289 25 6.11 (3.30-11.31) 5.83 (3.17-10.74) 6.98 (3.56-13.68)  
Lifetime N o sex partners
 1 964 8 Ref. Ref. Ref.  
 2 361 11 3.67 (1.46-9.20) 3.64 (1.45-9.14) 3.45 (1.37-8.65) 0.052
 ≥3 1455 85 7.02 (3.39-4.56) 6.92 (3.32-14.40) 6.16 (2.89-13.13) <0.001
 Prefer not to answer 273 24 10.63 (4.72-23.92) 10.43 (4.63-23.50) 11.12 (4.72-26.17)  
  1. aAnt: antibodies;
  2. bORs are adjusted for age only.
  3. cORs are adjusted for age, smoking, No of children, age at sexual debut, C.trachomatis diagnosis, partners in the last 5 years and partners before the last 5 years with the exception of the ORs for lifetime No sex partners which were not adjusted for partners in the last 5 years or partners before the last 5 years due to multi-collinearity between these three variables.
  4. dp-values are for OR2
  5. en/a: not applicable