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Table 3 Odds ratios for HPV18 seropositivity in women with normal cytology

From: Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study

Characteristic

Anti-HPV18 Atb a

Unadjusted OR (95% CI)

OR1 b(95% CI)

OR2 c(95% CI)

p-trend/p-nominal d

-ve

+ve

All women

3053

128

    

Age

 30-39

510

22

Ref.

n/a

Ref.

 

 40-49

421

17

0.94 (0.49-1.79)

n/a

0.92 (0.48-1.78)

0.893

 50-59

1651

77

1.08 (0.67-1.79)

n/a

1.23 (0.74-2.03)

0.378

 60-64

471

12

0.59 (0.29-1.21)

n/a

0.76 (0.36-1.59)

 

Smoking

 Never

1809

58

Ref.

Ref.

Ref.

 

 Past

928

59

1.98 (1.37-2.88)

1.99 (1.37-2.89)

1.40 (0.94-2.07)

n/ae

 Current

316

11

1.09 (0.56-2.09)

1.07 (0.56-2.07)

0.70 (0.36-1.39)

0.065

N o of children

 0

311

15

Ref.

Ref.

Ref.

 

 1

359

18

1.04 (0.51-2.10)

1.06 (0.52-2.14)

1.13 (0.55-2.34)

0.352

 2

1229

62

1.04 (0.59-1.86)

1.06 (0.59-1.89)

1.39 (0.75-2.55)

0.174

≥3

1154

33

0.59 (0.32-1.10)

0.60 (0.32-1.13)

0.86 (0.44-1.66)

 

Age at sexual debut

≥18

1800

64

Ref.

Ref.

Ref.

 

 17

463

23

1.40 (0.86-2.27)

1.35 (0.83-2.20)

0.99 (0.60-1.64)

0.941

 16

428

24

1.58 (0.97-2.55)

1.53 (0.94-2.48)

1.02 (0.61-1.71)

0.605

 15

171

6

0.99 (0.42-2.31)

0.96 (0.41-2.25)

0.63 (0.26-1.52)

 

 <15

108

8

2.08 (0.97-4.46)

2.02 (0.94-4.34)

1.25 (0.56-2.78)

 

 Prefer not to answer

83

3

1.02 (0.31-3.30)

1.01 (0.31-3.28)

0.39 (0.11-1.42)

 

C. trachomatis diagnosis

 No

2898

114

Ref.

Ref.

Ref.

 

 Yes

123

10

2.07 (1.06-4.05)

2.02 (1.03-3.97)

1.58 (0.79-3.17)

n/ae

 Prefer not to answer

32

4

3.18 (1.11-9.14)

3.15 (1.09-9.09)

2.16 (0.71-6.55)

0.187

Partners in last 5y

 0-1

2770

114

Ref.

Ref.

Ref.

 

 2

129

5

0.94 (0.38-2.35)

0.92 (0.37-2.29)

0.73 (0.29-1.85)

0.939

 ≥3

107

8

1.82 (0.86-3.82)

1.83 (0.86-3.92)

1.34 (0.61-2.95)

0.499

 Prefer not to answer

47

1

0.52 (0.07-3.78)

0.52 (0.07-3.82)

0.30 (0.04-2.36)

 

Partners before the last 5y

 0-1

1295

19

Ref.

Ref.

Ref.

 

 2

280

14

3.42 (1.70-6.91)

3.32 (1.64-6.70)

3.14 (1.55-6.39)

0.032

 ≥3

1189

70

4.07 (2.44-6.80)

3.95 (2.35-6.61)

3.49 (2.00-6.06)

<0.001

 Prefer not to answer

289

25

6.11 (3.30-11.31)

5.83 (3.17-10.74)

6.98 (3.56-13.68)

 

Lifetime N o sex partners

 1

964

8

Ref.

Ref.

Ref.

 

 2

361

11

3.67 (1.46-9.20)

3.64 (1.45-9.14)

3.45 (1.37-8.65)

0.052

 ≥3

1455

85

7.02 (3.39-4.56)

6.92 (3.32-14.40)

6.16 (2.89-13.13)

<0.001

 Prefer not to answer

273

24

10.63 (4.72-23.92)

10.43 (4.63-23.50)

11.12 (4.72-26.17)

 
  1. aAnt: antibodies;
  2. bORs are adjusted for age only.
  3. cORs are adjusted for age, smoking, No of children, age at sexual debut, C.trachomatis diagnosis, partners in the last 5 years and partners before the last 5 years with the exception of the ORs for lifetime No sex partners which were not adjusted for partners in the last 5 years or partners before the last 5 years due to multi-collinearity between these three variables.
  4. dp-values are for OR2
  5. en/a: not applicable
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BMC Infectious Diseases

ISSN: 1471-2334

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