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Table 2 Odds ratios for HPV16 seropositivity in women with normal cytology

From: Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study

Characteristic

Anti-HPV16 Atb a

Unadjusted OR (95% CI)

OR1 b(95% CI)

OR2 c(95% CI)

p-trend/p-nominal d

-ve

+ve

All women

2659

522

    

Age

 30-39

410

122

Ref.

n/a

Ref.

 

 40-49

345

93

0.90 (0.66-1.22)

n/a

0.93 (0.67-1.28)

<0.001

 50-59

1469

259

0.59 (0.46-0.75)

n/a

0.71 (0.54-0.92)

0.003

 60-64

435

48

0.37 (0.26-0.53)

n/a

0.53 (0.36-0.78)

 

Smoking

 Never

1626

241

Ref.

Ref.

Ref.

 

 Past

781

206

1.77 (1.44-2.18)

1.76 (1.43-2.16)

1.18 (0.95-1.48)

n/ae

 Current

252

75

2.00 (1.49-2.68)

1.91 (1.43-2.57)

1.16 (0.85-1.60)

0.310

N o of children

 0

245

81

Ref.

Ref.

Ref.

 

 1

296

81

0.83 (0.58-1.18)

0.82 (0.58-1.17)

0.91 (0.63-1.31)

0.146

 2

1087

204

0.57 (0.43-0.76)

0.60 (0.45-0.81)

0.81 (0.59-1.10)

0.823

 ≥3

1031

156

0.46 (0.34-0.62)

0.51 (0.38-0.70)

0.78 (0.56-1.07)

 

Age at sexual debut

 ≥18

1609

255

Ref.

Ref.

Ref.

 

 17

392

94

1.51 (1.16-1.96)

1.44 (1.11-1.87)

0.95 (0.72-1.26)

 

 16

370

82

1.40 (1.06-1.84)

1.29 (0.98-1.70)

0.79 (0.59-1.07)

0.315

 15

132

45

2.15 (1.50-3.09)

1.89 (1.31-2.74)

1.06 (0.71-1.57)

0.408

 <15

84

32

2.40 (1.57-3.69)

2.13 (1.38-3.29)

1.00 (0.63-1.58)

 

 Prefer not to answer

72

14

1.23 (0.68-2.21)

1.24 (0.69-2.25)

0.56 (0.29-1.12)

 

C. trachomatis diagnosis

 No

2545

467

Ref.

Ref.

Ref.

 

 Yes

87

46

2.88 (1.99-4.17)

2.73 (1.88-3.97)

1.89 (1.27-2.80)

n/ae

 Prefer not to answer

27

9

1.81 (0.85-3.88)

1.73 (0.80-3.72)

1.21 (0.55-2.66)

0.006

Partners in last 5y

 0-1

2457

427

Ref.

Ref.

Ref.

 

 2

86

48

3.20 (2.22-4.63)

2.93 (2.02-4.25)

2.18 (1.48-3.21)

0.165

 ≥3

76

39

2.95 (1.98-4.39)

2.47 (1.64-3.71)

1.49 (0.97-2.29)

<0.001

 Prefer not to answer

40

8

1.15 (0.53-2.47)

1.23 (0.57-2.65)

0.77 (0.33-1.80)

 

Partners before the last 5y

 0-1

1240

74

Ref.

Ref.

Ref.

 

 2

249

45

3.12 (2.11-4.62)

2.99 (2.01-4.44)

2.92 (1.96-4.36)

<0.001

 ≥3

934

325

5.89 (4.51-7.69)

5.45 (4.17-7.13)

4.65 (3.48-6.22)

<0.001

 Prefer not to answer

236

78

5.79 (4.07-8.23)

5.47 (3.86-7.76)

5.88 (3.95-8.76)

 

Lifetime N o sex partners

 1

934

38

Ref.

Ref.

Ref.

 

 2

337

35

2.55 (1.59-4.11)

2.46 (1.52-3.96)

2.35 (1.45-3.80)

<0.001

 ≥3

1166

374

7.89 (5.59-11.14)

7.30 (5.16-10.33)

6.50 (4.53-9.34)

<0.001

 Prefer not to answer

222

75

8.34 (5.50-12.65)

8.08 (5.32-12.27)

8.08 (5.14-12.69)

 
  1. aAnt: antibodies;
  2. bORs are adjusted for age only.
  3. cORs are adjusted for age, smoking, No of children, age at sexual debut, C.trachomatis diagnosis, partners in the last 5 years and partners before the last 5 years with the exception of the OR for lifetime No sex partners which were not adjusted for partners in last 5 years or partners before the last 5 years due to multi-collinearity between these three variables.
  4. dp-values are for OR2.
  5. en/a: not applicable.