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Table 2 Odds ratios for HPV16 seropositivity in women with normal cytology

From: Human papillomavirus 16/18 seroprevalence in unvaccinated women over 30 years with normal cytology and with high grade cervical abnormalities in Australia: results from an observational study

Characteristic Anti-HPV16 Atb a Unadjusted OR (95% CI) OR1 b(95% CI) OR2 c(95% CI) p-trend/p-nominal d
-ve +ve
All women 2659 522     
Age
 30-39 410 122 Ref. n/a Ref.  
 40-49 345 93 0.90 (0.66-1.22) n/a 0.93 (0.67-1.28) <0.001
 50-59 1469 259 0.59 (0.46-0.75) n/a 0.71 (0.54-0.92) 0.003
 60-64 435 48 0.37 (0.26-0.53) n/a 0.53 (0.36-0.78)  
Smoking
 Never 1626 241 Ref. Ref. Ref.  
 Past 781 206 1.77 (1.44-2.18) 1.76 (1.43-2.16) 1.18 (0.95-1.48) n/ae
 Current 252 75 2.00 (1.49-2.68) 1.91 (1.43-2.57) 1.16 (0.85-1.60) 0.310
N o of children
 0 245 81 Ref. Ref. Ref.  
 1 296 81 0.83 (0.58-1.18) 0.82 (0.58-1.17) 0.91 (0.63-1.31) 0.146
 2 1087 204 0.57 (0.43-0.76) 0.60 (0.45-0.81) 0.81 (0.59-1.10) 0.823
 ≥3 1031 156 0.46 (0.34-0.62) 0.51 (0.38-0.70) 0.78 (0.56-1.07)  
Age at sexual debut
 ≥18 1609 255 Ref. Ref. Ref.  
 17 392 94 1.51 (1.16-1.96) 1.44 (1.11-1.87) 0.95 (0.72-1.26)  
 16 370 82 1.40 (1.06-1.84) 1.29 (0.98-1.70) 0.79 (0.59-1.07) 0.315
 15 132 45 2.15 (1.50-3.09) 1.89 (1.31-2.74) 1.06 (0.71-1.57) 0.408
 <15 84 32 2.40 (1.57-3.69) 2.13 (1.38-3.29) 1.00 (0.63-1.58)  
 Prefer not to answer 72 14 1.23 (0.68-2.21) 1.24 (0.69-2.25) 0.56 (0.29-1.12)  
C. trachomatis diagnosis
 No 2545 467 Ref. Ref. Ref.  
 Yes 87 46 2.88 (1.99-4.17) 2.73 (1.88-3.97) 1.89 (1.27-2.80) n/ae
 Prefer not to answer 27 9 1.81 (0.85-3.88) 1.73 (0.80-3.72) 1.21 (0.55-2.66) 0.006
Partners in last 5y
 0-1 2457 427 Ref. Ref. Ref.  
 2 86 48 3.20 (2.22-4.63) 2.93 (2.02-4.25) 2.18 (1.48-3.21) 0.165
 ≥3 76 39 2.95 (1.98-4.39) 2.47 (1.64-3.71) 1.49 (0.97-2.29) <0.001
 Prefer not to answer 40 8 1.15 (0.53-2.47) 1.23 (0.57-2.65) 0.77 (0.33-1.80)  
Partners before the last 5y
 0-1 1240 74 Ref. Ref. Ref.  
 2 249 45 3.12 (2.11-4.62) 2.99 (2.01-4.44) 2.92 (1.96-4.36) <0.001
 ≥3 934 325 5.89 (4.51-7.69) 5.45 (4.17-7.13) 4.65 (3.48-6.22) <0.001
 Prefer not to answer 236 78 5.79 (4.07-8.23) 5.47 (3.86-7.76) 5.88 (3.95-8.76)  
Lifetime N o sex partners
 1 934 38 Ref. Ref. Ref.  
 2 337 35 2.55 (1.59-4.11) 2.46 (1.52-3.96) 2.35 (1.45-3.80) <0.001
 ≥3 1166 374 7.89 (5.59-11.14) 7.30 (5.16-10.33) 6.50 (4.53-9.34) <0.001
 Prefer not to answer 222 75 8.34 (5.50-12.65) 8.08 (5.32-12.27) 8.08 (5.14-12.69)  
  1. aAnt: antibodies;
  2. bORs are adjusted for age only.
  3. cORs are adjusted for age, smoking, No of children, age at sexual debut, C.trachomatis diagnosis, partners in the last 5 years and partners before the last 5 years with the exception of the OR for lifetime No sex partners which were not adjusted for partners in last 5 years or partners before the last 5 years due to multi-collinearity between these three variables.
  4. dp-values are for OR2.
  5. en/a: not applicable.