Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients

Table 3 Known SNPs within CNS peaks identified in the region from the initiation site to 3.5 kb upstream of IFNGR1

SNP	Physical position bp	CNS peak ^a	Alleles	MAF ^b	Loss/gain TFBS ^c
rs55995532	137541178	3	A/C	----	C/EBbeta
rs17175064	137541195	3	C/A	0.006	-
rs1327473	137541230	3	A/T	0.017	AP-1, C/EBPa1P
rs56273545	137541233	3	A/G	----	-
rs56178591	137541279	3	C/T	----	MAZ, ZNF263
rs17175057	137541297	3	G/A	EUR, 0.023	SP1, KLF7
rs17175050	137541521	2	A/T	0.009	NF-1/GATA-1 ZBTB3

^aPeaks are numbered in Figure 1. ^bglobal MAF from SNPDB, −--- indicates no population data available in SNPDB, EUR indicates frequency in PGA European Panel. MAF, minor allele frequency; ^cTFBS, transcription factor binding site; grey shading, loss of TFBS; italics, gain of TFBS.

ISSN: 1471-2334