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Table 2 Characteristics of NTM culture positive patients stratified by LAM result at grade 1 cut-point

From: Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria – experiences from the Danish Cystic Fibrosis cohort study

Characteristic at time of first positive NTM culture

LAM positive ( n  = 9)

LAM negative ( n  = 14)

p -value

Median age (IQR), y

19.7 (13.7 – 25.6)

16.1 (11.9 – 24.0)

0.41

Female, %

88.9

28.6

0.01

Homozygote for Delta 508, %

78.8

85.7

0.62

Median FEV1% of pred. (IQR)

80.0 (70.3 – 84.8)

70.0 (66.3 – 83.5)

0.59

Diabetes mellitus, %

11.1

28.6

0.32

Structurally defective MBL allele*, %

55.6

7.1

0.01

Other chronic infection, %

77.8

50.0

0.18

Received NTM treatment, %

55.6

57.1

0.94

Number of positive NTM cultures

11.0 (3.5 – 19.5)

6.0 (1.8 – 14.5)

0.68

MABSC, %

88.9

64.3

0.19

Fulfilled ATS criteria for NTM, %

88.9

78.6

0.52

Median time positive for NTM (IQR), y

2.5 (1.0 – 4.0)

3.0 (1.0 – 5.0)

1.00

Chronic renal disease**, %

0

14.3

0.24

  1. MABSC = M. abscessus complex, MAC = M. avium complex, NTM = nontuberculous mycobacteria, IQR = Interquartile range, FEV1% = forced expiratory volume in 1 second as percent of predicted for age, height and sex, ATS = American Thoracic Society.
  2. *XA/B (n = 3) or YA/B (n = 3) genotype.
  3. **Defined as renal-clearance below 107 ml/min for adult men and 87 ml/min for adult women or in case of missing renal-clearance measurement, a mean serum creatinine at time of LAM testing over 105 or 90 μmol/L for adult men and women respectively or > 35, 40, 50, 55, 65 or 70 μmol/L for age groups 3-5 y, 6-7 y, 8-9 y, 10-11 y, 12-13 y and 14-15 y respectively.