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Table 1 Summary of the 6 patients with 10 episodes of Salmonella Prosthetic joint infections 1

From: Prosthetic joint infection due to Salmonellaspecies: a case series

Patient no. Prosthetic joint (indication) Co-morbidities Prosthesis age at time of infection Clinical presentation Microbiology Antimicrobial therapy Surgical management Failed treatment Follow-up duration
1. Left TKA (RA) RA, Bladder cancer 3 years Deep joint pain, discomfort x 4 months Salmonella enterica serovar Enteritidis (aspirate) Oral TMP-SMX x 12 weeks Aspiration only Yes 3 months
  ‘’ ‘’ 3 years Pain in region of joint, unresolved after 3 months of suppressive oral therapy ‘’ (operativesample) Oral TMP-SMX x 8 weeks Removal, debridement and arthrodesis No 15 years
2. Right THA (DJD) Colonic polyps status post colectomy 6 years Cholecystectom y 2 weeks prior, with positive blood and stool cultures. Fever and joint pain x 5 days Salmonella enterica serovar Enteritidis (operative sample) IV ampicillin x 4 weeks and oral amoxicillin x 10 months Debride and retain Yes 11 months
  ‘’ ‘’ 7 years Pain in region of prosthetic joint, unresolved after 11 months of suppressive oral therapy ‘’ (operative sample) IV ampicillin x 4 weeks Removal, debridement and arthrodesis No 8 years
3 Left THA (dislocated hip) Diabetes mellitus 5 months Fever, joint pain, joint swelling starting 5 day prior, negative stool cultures but diarrhea 1 week earlier Salmonella enterica serovar Choleraesui s (aspirate) Oral ampicillin x 8 weeks Aspiration only Yes 2 months
  ‘’ ‘’ 7 months Continuing symptoms ‘’ (operative sample) Oral ampicillin x 4 weeks Two- stage exchange No 21 years
4. Left THA (DJD) CLL, multiple skin cancers 4 years Fever, chills x 2 days, Joint pain and swelling x 2 days Salmonella enterica serovar Enteritidis (operative sample) Oral ciprofloxacin x 8 weeks Two- stage exchange No 10 years
5. Left THA (aseptic necrosis) Ulcerative colitis, now on 6-MP 5 months Fever and joint pain x 2 weeks Salmonella enterica serovar Enteritidis (operative sample) IV ceftriaxone x 6 weeks Two- stage exchange No 12 years
6. Left THA (DJD) CKD, h/o stroke 9 years Complicated Salmonella UTI and septic shock 1 month prior, now left hip joint pain x 4 days Salmonella bongori (aspirate) Oral ciprofloxacin x 8 weeks Aspiration only Yes 2 months
  ‘’ ‘’ 9 years Continuing hip pain ‘’ + MSCONS, viridans group Streptococc us sp., (operative sample) IV ceftriaxone x 6 weeks Two- stage exchange No 4 years
  1. 1M- male, F- female, TKA- total knee arthroplasty, THA- total hip arthroplasty, RA- rheumatoid arthritis, TMP-SMX – trimethoprim-sulfamethoxazole, DJD- degenerative joint disease, CLL- chronic lymphocytic leukemia, 6-MP- 6-mercaptopurine, CKD- chronic kidney disease, UTI- urinary tract infection, MSCONS- methicillin- susceptible Coagulase negative Staphylococci.