Table 5 DEPDC5 genetic variations among chronic HCV-infected patients (Group 1) and cirrhotic HCV-infected patients diagnosed with HCC (Group 3)
SNPs | Genotype/allele distribution | Chronic (450) | Cirrhosis + HCC (151) | OR (95% C.I.) | χ 2 | p value |
|---|---|---|---|---|---|---|
rs1012068 | GG | 24 (5.3%) | 9 (6%) | 1.419 (0.629-3.201) | 0.720 | 0.397 |
GT | 180 (40%) | 77 (51%) | 1.619 (1.105-2.372) | 6.160 | 0.013 | |
TT | 246 (54.7%) | 65 (43%) | Ref | Â | Â | |
GG + GT.VS.TT |  |  | 1.595 (1.100-2.314) | 6.110 | 0.013 | |
TT + GT.VS.GG | 0.889 (0.404-1.957) | 0.090 | 0.769 | |||
Allele | Â | Â | Â | Â | Â | |
G | 228 (25.3%) | 95 (31.5%) | 1.353(1.017-1.800) | 4.310 | 0.038 | |
T | 672 (74.7%) | 207 (68.5%) | Â | Â | Â | |
rs5998152 | CC | 30 (6.7%) | 9 (6%) | 1.163 (0.526-2.572) | 0.140 | 0.701 |
CT | 172 (38.2%) | 78 (52%) | 1.757 (1.197-2.579) | 8.390 | 0.004 | |
TT | 248 (55.1%) | 64 (42%) | Ref | Â | Â | |
CC + CT.VS.TT |  |  | 1.669 (1.150-2.422) | 7.340 | 0.007 | |
TT + CT.VS.CC | 1.127 (0.522-2.431) | 0.090 | 0.760 | |||
Allele | Â | Â | Â | Â | Â | |
C | 232 (25.8%) | 96 (32%) | 1.342 (1.010-1.784) | 4.120 | 0.043 | |
T | 668 (74.2%) | 206 (68%) |