Table 4 DEPDC5 genetic variations between chronic HCV-infected patients (Group 1) and cirrhotic HCV-infected patients (Group 2)
SNPs | Genotype/allele distribution | Chronic (450) | Cirrhosis (124) | OR (95% C.I.) | χ 2 | p value |
|---|---|---|---|---|---|---|
rs1012068 | GG | 24 (5.3%) | 9 (7.3%) | 1.809 (0.794-4.121) | 2.040 | 0.154 |
GT | 180 (40%) | 64 (51.6%) | 1.715 (1.132-2.597) | 6.570 | 0.010 | |
TT | 246 (54.7%) | 51 (41.1%) | Ref | Â | Â | |
GG + GT.VS.TT |  |  | 1.726 (1.154-2.583) | 7.140 | 0.008 | |
TT + GT.VS.GG |  |  | 0.720 (0.326-1.591) | 0.660 | 0.415 | |
Allele | Â | Â | Â | Â | Â | |
G | 228 (25.3%) | 82 (33%) | 1.456 (1.074-1.974) | 5.900 | 0.015 | |
| Â | T | 672 (74.7%) | 166 (67%) | |||
rs5998152 | CC | 30 (6.7%) | 7 (5.7%) | 1.157 (0.481-2.782) | 0.110 | 0.744 |
CT | 172 (38.2%) | 67 (54%) | 1.932 (1.276-2.925) | 9.860 | 0.002 | |
TT | 248 (55.1%) | 50 (40.3%) | Ref | Â | Â | |
CC + CT.VS.TT |  |  | 1.817 (1.213-2.722) | 8.520 | 0.004 | |
TT + CT.VS.CC | 1.194 (0.511-2.787) | 0.170 | 0.682 | |||
C | 232 (25.8%) | 81(33%) | 1.397 (1.030-1.894) | 4.650 | 0.031 | |
T | 668 (74.2%) | 167(67%) |