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Table 8 Microbiological success (eradication of bacteriuria) in the different evaluation sets

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

Evaluation set

Nitroxoline

Controls

Difference (%) (95%-CI)

Odds ratio (95%-CI)

mMITT

192/211 (91.0%)

203/213 (95.3%)

−3.4 (−9.7 to 3.0)

0.47 (0.21 to 1.06)

PP

184/200 (92.0%)

197/206 (95.6%)

−2.2 (−8.2 to 3.7)

0.47 (0.19 to 1.14)

mPP

185/205 (90.2%)

197/210 (93.8%)

−2.9 (−9.9 to 4.1)

0.60 (0.28 to 1.27)

  1. mMITT-modified microbiological intention to treat; PP-per protocol; mPP-modified per protocol.
  2. Difference: nitroxoline – controls.
  3. Odds Ratio: nitroxoline vs controls.
  4. Estimation by logistic regression with random center effect.