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Table 4 Two controlled open clinical studies in a total of 148 patients with nitroxoline (NTX) versus norfloxacin (NFX) or cotrimoxazole (CTX); SMX-sulphamethoxazole; TMP-trimethoprim

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

First author

Year

Pat.(n)

Indication (T/P)

Antibiotic and dosage

Duration

Success rate

Adverse events

Schülke [67]

1986

51 NTX

T: postop., uncompl. UTI

750 mg NTX/d vs. 800 mg NFX/d

3 days

60.8% NTX 59.2% NFX

0%

49 NFX

Dodat [68]

1988

48 children

P: postop. UTI (ureteral reflux)

10 mg NTX/kg/d

30–60 days

95% NTX

6% NTX

0–8 years

vs. 15 mg SMX/ 3 mg TMP/kg/d

95% CTX

5% CTX

  1. T-therapy; P-prophylaxis, UTI-urinary tract infection.