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Table 3 Eleven uncontrolled clinical studies on treatment and prophylaxis of UTI with nitroxoline in 259 children

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

First author Year Patients (n) Indication (T/P) Dosage Duration Success rate Adverse events
Lecornu [57] 1974 25 children T: compl. and uncompl. UTI 50–400 mg/d as suspension 4–12 days 72% 8% nausea
0–13 years
Roussel [58] 1974 24 children T: compl. and uncompl. UTI 10 mg/kg/d as suspension 10 days- 6 months 79% 0%
7 days–6 months
Raynaud [59] 1974 19 children T: compl. and uncompl. UTI 10 mg/kg/d as suspension 20 days 69% 10% nausea
0–10 years
Luckel [60] 1975 25 children P: compl. and uncompl. UTI 10–20 mg/kg/d as suspension 17–55 days 83% 0%
0–8.5 years
Viville [61] 1975 22 children P: compl. UTI 10–30 mg/kg/d as suspension 3–6 months 86% 0%
2 months-17 years
Chable [62] 1975 28 children T: compl. and uncompl. UTI 10–20 mg/kg/d as suspension 10 days 81% 0%
2 month-14.5 years
Battin [63] 1975 30 children P: compl. and uncompl. UTI 10 mg/kg/d as suspension 6 weeks 90% 0%
2 month-10 years
Sorez [64] 1975 30 children T: compl. and uncompl. UTI 10–25 mg/kg/d as suspension 10 – 17 days 73.7% uncompl. UTI
40% compl. UTI
0%
10 days-8 years
Neimann [65] 1975 21 children T/P: compl. and uncompl. UTI 25–400 mg/d as suspension 4 days-4 months 90% 10% nausea
26 days-8 years
Machecourt [66] 1976 23 children T: compl. and uncompl. UTI 10–20 mg/kg/d as suspension 10 days 91% 0%
21 days-14 years
Lambert-Zechovsky [24] 1987 12 children T: uncompl. UTI 20 mg/kg/d as suspension 10 days 66% (91% incl. non-compliance) -
aver. 4 years
  1. n-number; T-therapy; P-prophylaxis; UTI-urinary tract infection.