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Table 2 Fifteen uncontrolled clinical studies with nitroxoline in 947 adult patients of both genders

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

First author Year Pat (n) Indication (T/P) Dosage Duration Success rate Adverse events
Kuss [43] 1962 72 T: acute cUTI & uUTI 400 mg/d 20–45 days 78% 1.3% gastrointestinal
Moreau [44] 1962 20 T: acute cUTI 400–500 mg/d 8–10 (−45) days 90% 5% gastrointestinal
v. Rütte [45] 1969 200 P: chronic rUTI 300–500 mg/d 2–3 months 80% 0%
shortly 800 mg/d 1 day
Uhlir [46] 1972 20 T: acute UTI (7), chronic PN (13) 300 mg/d 14 days 100% 0%
Allal [47] 1973 264 T: UTI during pregnancy 300 mg/d 6 days > 75% No data
Bittard [48] 1974 50 P: post-op. catheter 7.5–10 mg/kg/d 6 weeks 92% Few gastrointestinal
Schlesinger [49] 1975 65 T: chronic PN (62), chronic prostatitis (3) 300–500 mg/d 10 days 80% clinical 0%
Aubert [50] 1976 28 T: post-op. catheter, after endoscopy 200–300 mg/d 10–15 days 72% 0%
Dufour [51] 1979 15 T: acute prostatitis 900–1600 mg/d 3–5 days 81% No data
Lenzner [52] 1983 60 T: fungal UTI 750 mg/d 10–20 days 80% 3.3% itching; few cases with nausea and vomiting
Schülke [53] 1984 50 T: postop., acute UTI after removal of urethral catheter for 3–10 days 750 mg/d 3 days 78% 0%
Sachse [54] 1984 44 P: chronic rUTI 750 mg/d 4 months 77% free of rUTI; rUTI rate decreased from 0.33 to 0.11/month 9% gastrointestinal
2.2% exanthema
Demontrond [55] 1986 15 T: candiduria in hospitalised patients 600 mg/d 10–30 days 87% 0%
Frobert [56] 1987 36 T: acute, uUTI in hospitalised patients 600 mg/d 10 days 93% bacteriological 5.5% gastrointestinal
87% clinical 2.7% nausea
2.7% dizziness
Cancet [27] 1987 8 T: urogenital fungal infections 600 mg/d 15 days 100% no data
  1. T-therapy; P-prophylaxis; UTI-urinary tract infection; uUTI-uncomplicated UTI; cUTI-complicated UTI; PN-pyelonephritis.