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Table 12 Laboratory parameters before and after treatment in the safety-set

From: Review of the literature and individual patients’ data meta-analysis on efficacy and tolerance of nitroxoline in the treatment of uncomplicated urinary tract infections

  Critical values Pretreatment Posttreatment
   Nitroxoline Contols p-value* Nitroxoline Contols p-value*
Glucose (mg/dl) < 55, >160 20/227 (8.8%) 12/226 (5.3%) 0.138 12/206 (5.8%) 7/207 (3.4%) 0.242
Creatinine (mg/dl) > 1.8 1/228 (0.4%) 1/227 (0.4%) 0.998 1/205 (0.5%) 0/207 (0%) -
Bilirubin (mg/dl) < 0.1, >2.0 3/226 (1.3%) 1/227 (0.4%) 0.337 2/205 (1.0%) 4/207 (1.9%) 0.426
SGOT –AST (U/l) < 35, > = 150 224/226 (99.1%) 225/226 (99.6%) 0.570 203/205 (99.0%) 206/207 (99.5%) 0.564
SGPT - ALT (U/l) < 35, > = 150 222/226 (98.2%) 225/226 (99.6%) 0.212 204/205 (99.5%) 207/207 (100%) -
gamma-GT (U/l) < 3, >38 9/227 (4.0%) 10/226 (4.4%) 0.807 9/205 (4.4%) 6/207 (2.9%) 0.412
Sodium (mmol/l) < 130, >150 8/228 (3.5%) 6/226 (2.7%) 0.603 11/205 (5.4%) 5/207 (2.4%) 0.132
Potassium (mmol/l) < 3.6, >6.0 22/228 (9.6%) 19/226 (8.4%) 0.628 19/205 (9.3%) 12/206 (5.8%) 0.229
Calcium (mmol/l) < 8, >11.5 229/229 (100%) 227/227 (100%) - 206/206 (100%) 206/206 (100%) -
Hemoglobin (g/dl) < 10, >17 0/227 (0%) 0/219 (0%) - 1/201 (0.5%) 2/204 (1.0%) 0.582
Hematocrit (%) < 32, >47 25/227 (11.0%) 33/220 (15.0%) 0.197 20/201 (10.0%) 33/204 (16.2%) 0.065
Erythrocytes (Mio/μl) < 4, >5.1 29/227 (12.8%) 14/220 (6.4%) 0.024 22/201 (10.9%) 26/205 (12.7%) 0.588
Leucocytes (Tsd/μl) < 4, >11.3 25/227 (11.0%) 21/220 (9.5%) 0.605 13/200 (6.5%) 16/204 (7.8%) 0.614
Neutrophiles (%) < 39, >75 22/225 (9.8%) 37/221 (16.7%) 0.031 15/199 (7.5%) 13/203 (6.4%) 0.656
Eosinophiles (%) < 1, >10 10/223 (4.5%) 19/219 (8.7%) 0.080 11/199 (5.5%) 8/203 (3.9%) 0.399
Basophiles (%) 0, >15 38/222 (17.1%) 47/220 (21.4%) 0.257 29/199 (14.6%) 38/203 (18.7%) 0.266
Lymphocytes (%) < 10, >50 9/221 (4.1%) 12/220 (5.5%) 0.391 7/198 (3.5%) 11/203 (5.4%) 0.382
Monocytes (%) < 3, >25 7/223 (3.1%) 14/220 (6.4%) 0.117 9/199 (4.5%) 6/203 (3.0%) 0.410
Retikulocytes (%) < 0.5, >2 220/224 (98.2%) 212/218 (97.2%) 0.493 198/200 (99.0%) 200/205 (97.6%) 0.227
Thrombocytes (Tsd/μl) < 150, >450 11/225 (4.9%) 8/218 (3.7%) 0.529 10/201 (5.0%) 8/204 (3.9%) 0.608
BSR (mm/1 h) < 5, >11 134/203 (66.0%) 124/202 (61.4%) 0.343 106/179 (59.2%) 114/187 (61.0%) 0.756
BSR (mm/2 h) > 25 82/202 (40.6%) 88/200 (44.0%) 0.470 44/178 (24.7%) 57/186 (30.6%) 0.207
  1. BSR-blood sedimentation rate.
  2. *comparison of nitroxoline vs. controls, logistic regression with random center effect.