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Table 3 Genetic characteristics of Neisseria gonorrhoeae with increased MICs (n = 15) to ceftriaxone (≥0.125 mg/L)

From: Antimicrobial susceptibility of Neisseria gonorrhoeaeisolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011–2012): genetic characteristics of isolates with reduced sensitivity to ceftriaxone

Isolate no. Ceftriaxone MICs (mg/L) Antimicrobial characteristics NG-MAST PBP2 allele Polymorphisms in:
porB tbpB STs MtrR PorB1b PBP1 PilQ
NJ-1 0.25 CMRNG, CipR# 5658 111 9530* XVIII −57A del, A39T G120K, A121D L421P wt
NJ-2 0.25 CMRNG, CipR 5175 328 8737 XVIII −57A del, A39T G120K, A121D L421P wt
NJ-3 0.125 PPNG, CipR 5659 107 9531* XVIII −57A del G120K, A121G L421P wt
NJ-4 0.125 PP/TRNG, CipR 1053 186 3289 XVIII −57A del G120K, A121D L421P wt
NJ-5 0.125 PPNG, CipR 1854 33 9532* XLI** −57A del G120N, A121D L421P wt
NJ-6 0.125 PP/TRNG, CipR 543 294 9533* XVIII A39T G120K, A121G L421P wt
NJ-7 0.125 CMRNG, CipR 5660 186 9534* XVIII −57A del G120K, A121G L421P wt
NJ-8 0.125 CMRNG, CipR 505 135 2186 XVIII −57A del G120K, A121D L421P wt
NJ-9 0.125 CMRNG, CipR 1285 4 9535* XIII −57A del, G45D G120K, A121D L421P wt
NJ-10 0.125 TRNG, CipR 4 831 3746 XIII −57A del G120K, A121D L421P wt
NJ-11 0.125 CMRNG, CipR 3530 4 9536* XVIII −57A del G120K, A121G L421P wt
NJ-12 0.125 CMRNG, CipR 1198 156 2461 XVIII −57A del, A39T G120K, A121G L421P wt
NJ-13 0.125 CMRNG, CipR 5661 4 5061 XVIII −57A del, G45D G120K, A121N L421P wt
NJ-14 0.125 CMRNG, CipR 2978 1058 9537* XII −57A del G120K, A121D L421P wt
NJ-15 0.125 TRNG, CipR 543 438 9538* XVIII −57A del G120K, A121G L421P wt
  1. wt, wild type.
  2. *New NG-MAST STs detected in this study.
  3. **A new PBP2 allele previously not identified was named XLI according to previously used Nomenclature.
  4. #isolates exhibiting resistance to ciprofloxacin (MIC ≥ 1 mg/L).
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BMC Infectious Diseases

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