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Table 4 Factors associated with 12-month outcomes following cART initiation

From: The effect of adherence to guidelines for initial antiretroviral therapy on 1-year outcomes: a French cohort study

 

cART modification before 12 month

HIV-RNA <50 copies/mL at 12 month

CD4 variation from baseline

Characteristic

aOR*

P

aOR*

P

aRC*

P

cART modification

**

**

0.19 (0.15-0.24)

<.001

-68.2 (-84.5;-52.0)

<.001

Outside "what-to-start" guidelines

1.90 (1.45-2.49)

<.001

0.67 (0.45-1.00)

.05

-

-

Year of guidelines (ref: 2000)

      

2002

0.63 (0.42-0.97)

.03

0.96 (0.60-1.53)

-

4.4 (-26.2-34.9)

-

2004

0.57 (0.37-0.87)

.009

1.44 (0.90-2.31)

-

(14.0-75.5)

.004

2006

0.33 (0.22-0.58)

<.001

2.07 (1.31-3.28)

.002

51.4 (22.2-80.6)

.001

2008

0.40 (0.27-0.58)

<.001

2.05 (1.32-3.17)

.001

35.9 (7.7-64.0)

.01

2010

0.40 (0.26-0.62)

<.001

1.95 (1.19-3.20)

.008

27.6 (-3.9-59.1)

-

Male gender

0.76 (0.59-0.96)

.02

-

-

-

-

HBV/HCV coinfection

-

-

-

-

-26.1 (-49.6;-2.6)

.03

CDC stage C

1.90 (1.45-2.49)

<.001

0.54 (0.40-0.73)

<.001

-39.4 (-60.5;-18.3)

<.001

HIV-RNA >105 cps/mL

-

-

**

**

61.0 (44.3-77.7)

<.001

  1. Abbreviations: HBV hepatitis B virus, HCV hepatitis C virus, CDC Centers for Disease Control and Prevention, HIV human immunodeficiency virus, aOR adjusted odds ratio, aRC adjusted regression coefficient.
  2. Variables not retained in the final multivariate models: age, HIV risk factor, baseline CD4, delay from HIV diagnosis to cART initiation, adherence to "when-to-start" guidelines.
  3. *Adjusted on the other covariates.
  4. **Covariate not in the model.