Table 1 French guidelines for cART initiation from 2000 to 2010
a "when-to-start" guidelines | ||||||
|---|---|---|---|---|---|---|
2000 | 2002 | 2004 | 2006 | 2008 | 2010 | |
CDC B-C | Rec. | Rec. | Rec. | Rec. | Rec. | Rec. |
CD4 < 200/mm3 | Rec. | Rec. | Rec. | Rec. | Rec. | Rec. |
CD4 < 15% | Rec. | Rec. | Rec. | Rec. | Rec. | Rec. |
CD4 200-349/mm3 | Rec. | Opt. (1) | Rec. | Rec. | Rec. | Rec. |
CD4 350-500/mm3 | NR | Opt. (1) | Opt. (1) | Opt. (2) | Rec. | |
CD4 > 500/mm3 | NR | NR | NR | NR | Opt. (3) | |
b "what-to-start" guidelines | ||||||
2000 | 2002 | 2004 | 2006 | 2008 | 2010 | |
NRTIs Backbone | ||||||
ZDV + ddI | Pref. | Pref. | Alt. | Pref. | NR | NR |
ZDV +3TC | Pref. | Pref. | Pref. | Pref. | Alt. | Alt. |
d4T + ddI | Pref. | NR | NR | NR | NR | NR |
d4T +3TC | Pref. | Pref. | Alt. | NR | NR | NR |
ZDV + FTC | Alt. | Pref. | Pref. | Alt. | Alt. | |
TDF +3TC | Alt. | Pref. | Pref. | Pref. | Alt. | |
TDF + FTC | Alt. | Pref. | Pref. | Pref. | Pref. | |
ddI +3TC | Alt. | Pref. | Pref. | Pref. | NR | |
ddI + FTC | Alt. | Pref. | Pref. | Pref. | NR | |
ABC +3TC | Alt. | Pref. | Pref. | Pref. | Pref. | |
ABC + FTC | Alt. | Pref. | Pref. | Pref. | Alt. | |
ddI + TDF | Alt. | Alt. | NR | NR | NR | |
3 NRTIs combinations | ||||||
ABC +3TC + ddI | Alt. | NR | NR | NR | NR | |
ABC +3TC + d4T | Alt. | NR | NR | NR | NR | |
ZDV +3TC + ddI | Alt. | NR | NR | NR | NR | |
ABC +3TC + TDF | Alt. | NR | NR | NR | NR | |
TDF + ddI +3TC | Alt. | NR | NR | NR | NR | |
ZDV +3TC + ABC | Pref. | Pref. | Alt. (1) | Alt. (1) | NR | NR |
Other 3 NRTI combinations | Alt. | NR | NR | NR | NR | |
Unboosted PIs | ||||||
RTV | Pref. | NR | NR | NR | NR | NR |
IDV | Pref. | NR | NR | NR | NR | NR |
NFV | Pref. | Pref. | Alt. | NR | ||
Boosted PIs | ||||||
APVr | Alt. | Alt. | ||||
SQVr | Pref. | Pref. | Pref. | Pref. | Alt. | Alt. |
IDVr | Alt. | Pref. | Pref. | Alt. | Alt. | Alt. |
LPVr | Alt. | Pref. | Pref. | Pref. | Pref. | Pref. |
fAPVr | Pref. | Pref. | Pref. | Alt. | ||
ATVr | Alt. | Pref. | Pref. | |||
DRVr | NR | Alt. | Pref. | |||
NNRTIs | ||||||
EFV | Pref. | Pref. | Pref. | Pref. | Pref. | Pref. |
NVP | Pref. | Pref. | Pref. | Alt. | Alt. | Alt. |
Integrase Inhibitor | ||||||
RAL | Alt. | |||||
Antiretroviral combinations | ||||||
NNRTI + PI (boosted or not) | NR | NR | NR | |||
2 NRTIs +1 NNRTI | Pref. | Pref. | Pref. | Pref. | Pref. | Pref. |
2 NRTIs +1 PI | Pref. | Pref. | Alt. | NR | NR | NR |
2 NRTIs +1 boosted PI | Pref. | Pref. | Pref. | Pref. | Pref. | Pref. |
Boosted PI monotherapy | NR | NR | NR | |||