Skip to main content

Table 5 The association between two SNPs within the FTO gene and the risk of tuberculosis stratified by smoking and alcohol drinking

From: Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis

SNPs

Smoking

Alcohol drinking

Never (n = 1751)

Ever (n = 1366)

Never (n = 2325)

Ever (n = 747)

n (%)

OR (95% CI)a

Pa

n (%)

OR (95% CI)a

Pa

n (%)

OR (95% CI)a

Pa

n (%)

OR (95% CI)a

Pa

rs9939609 (T > A)

           

TT

1421( 81.15)

1

 

1078(78.92)

1

 

1868 (80.34)

1

 

594 (79.52)

1

 

AT

292(16.68)

0.98 (0.76-1.28)

0.906

235(17.20)

0.81(0.60-1.09)

0.163

394 (16.95)

0.91(0.72-1.13)

0.391

125 (16.73)

0.88(0.59-1.31)

0.536

AA

38( 2.17)

2.87( 1.43-5.77)

0.003

53(3.88)

4.69(2.08-10.59)

<0.001

63 (2.71)

2.42(1.36-4.32)

0.003

28 (3.75)

15.39(3.78-134.54)

<0.001

Add

 

1.20(0.98-1.48)

0.083

 

1.23(0.99-1.54)

0.065

 

1.12 (0.94-1.34)

0.200

 

1.51 (1.13-2.03)

0.006

Dom

 

1.11(0.87-1.42)

0.388

 

1.05(0.80-1.38)

0.720

 

1.03 (0.83-1.27)

0.799

 

1.27 (0.88-1.82)

0.196

Rec

 

2.88(1.44-5.77)

0.003

 

4.86(2.16-10.96)

<0.001

 

2.46 (1.39-4.39)

0.002

 

14.65(3.44-62.34)

<0.001

rs8050136 (C > A)

           

CC

1428(81.55)

1

 

1078(78.92)

1

 

1878 (80.77)

1

 

591 (77.49)

1

 

AC

316(18.05)

1.13(0.88-1.45)

0.336

276(20.20)

1.02(0.77-1.35)

0.888

434 (18.67)

1.05(0.84-1.30)

0.673

150 (20.08)

1.18(0.82-1.69)

0.383

AA

7(0.40)

0.22(0.03-1.81)

0.157

12(0.88)

0.68(0.21-2.17)

0.512

13 (0.56)

0.22(0.06-0.83)

0.025

6 (0.80)

2.12(0.38-11.68)

0.389

Add

 

1.06(0.83-1.34)

0.644

 

0.98(0.76-1.27)

0.896

 

0.96(0.78-1.18)

0.692

 

1.21(0.87-1.70)

0.260

Dom

 

1.10(0.86-1.41)

0.460

 

1.00(0.76-1.32)

0.988

 

1.00(0.81-1.24)

0.964

 

1.20(0.84-1.72)

0.313

Rec

 

0.21(0.03-1.76)

0.151

 

0.67(0.21-2.16)

0.507

 

0.22(0.06-0.82)

0.024

 

2.05(0.37-11.29)

0.409

  1. aadjusted for age, sex smoking and alcohol drinking where appropriate, Add additive model, Dom dominant model, Rec recessive model, OR odds ratio, CI confidence interval.