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Table 5 The association between two SNPs within the FTO gene and the risk of tuberculosis stratified by smoking and alcohol drinking

From: Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis

SNPs Smoking Alcohol drinking
Never (n = 1751) Ever (n = 1366) Never (n = 2325) Ever (n = 747)
n (%) OR (95% CI)a Pa n (%) OR (95% CI)a Pa n (%) OR (95% CI)a Pa n (%) OR (95% CI)a Pa
rs9939609 (T > A)            
TT 1421( 81.15) 1   1078(78.92) 1   1868 (80.34) 1   594 (79.52) 1  
AT 292(16.68) 0.98 (0.76-1.28) 0.906 235(17.20) 0.81(0.60-1.09) 0.163 394 (16.95) 0.91(0.72-1.13) 0.391 125 (16.73) 0.88(0.59-1.31) 0.536
AA 38( 2.17) 2.87( 1.43-5.77) 0.003 53(3.88) 4.69(2.08-10.59) <0.001 63 (2.71) 2.42(1.36-4.32) 0.003 28 (3.75) 15.39(3.78-134.54) <0.001
Add   1.20(0.98-1.48) 0.083   1.23(0.99-1.54) 0.065   1.12 (0.94-1.34) 0.200   1.51 (1.13-2.03) 0.006
Dom   1.11(0.87-1.42) 0.388   1.05(0.80-1.38) 0.720   1.03 (0.83-1.27) 0.799   1.27 (0.88-1.82) 0.196
Rec   2.88(1.44-5.77) 0.003   4.86(2.16-10.96) <0.001   2.46 (1.39-4.39) 0.002   14.65(3.44-62.34) <0.001
rs8050136 (C > A)            
CC 1428(81.55) 1   1078(78.92) 1   1878 (80.77) 1   591 (77.49) 1  
AC 316(18.05) 1.13(0.88-1.45) 0.336 276(20.20) 1.02(0.77-1.35) 0.888 434 (18.67) 1.05(0.84-1.30) 0.673 150 (20.08) 1.18(0.82-1.69) 0.383
AA 7(0.40) 0.22(0.03-1.81) 0.157 12(0.88) 0.68(0.21-2.17) 0.512 13 (0.56) 0.22(0.06-0.83) 0.025 6 (0.80) 2.12(0.38-11.68) 0.389
Add   1.06(0.83-1.34) 0.644   0.98(0.76-1.27) 0.896   0.96(0.78-1.18) 0.692   1.21(0.87-1.70) 0.260
Dom   1.10(0.86-1.41) 0.460   1.00(0.76-1.32) 0.988   1.00(0.81-1.24) 0.964   1.20(0.84-1.72) 0.313
Rec   0.21(0.03-1.76) 0.151   0.67(0.21-2.16) 0.507   0.22(0.06-0.82) 0.024   2.05(0.37-11.29) 0.409
  1. aadjusted for age, sex smoking and alcohol drinking where appropriate, Add additive model, Dom dominant model, Rec recessive model, OR odds ratio, CI confidence interval.