Skip to main content

Advertisement

Table 4 The association between two SNPs within the FTO gene and the risk of tuberculosis stratified by sex

From: Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis

SNPs Male (n = 2290) Female (n = 837)
n (%) OR (95% CI)a P a n (%) OR (95% CI)a P a
rs9939609 (T > A)      
TT 1823(79.61) 1   685 (81.84) 1  
AT 396(17.29) 0.93(0.74-1.16) 0.508 132 (15.77) 0.85(0.58-1.24) 0.397
AA 71(3.10) 4.15(2.23-7.70) <0.001 20 (2.39) 2.46(0.93-6.47) 0.069
Add   1.27 (1.06-1.51) 0.008   1.09(0.80-1.47) 0.590
Dom   1.13(0.91-1.39) 0.257   0.98(0.68-1.40) 0.893
Rec   4.20(2.27-7.79) <0.001   2.52(0.96-6.63) 0.061
rs8050136 (C > A)      
CC 1827 (79.78) 1   688 (82.20) 1  
AC 448 (19.56) 1.12(0.90-1.39) 0.301 145 (17.32) 0.98(0.68-1.42) 0.924
AA 15 (0.66) 0.53(0.18-1.52) 0.237 4 (0.48) 0.35(0.04-3.38) 0.364
Add   1.06(0.86-1.29) 0.591   0.93(0.66-1.32) 0.692
Dom   1.09(0.88-1.35) 0.413   0.51(0.18-1.49) 0.220
Rec   0.51(0.18-1.49) 0.220   0.35(0.04-3.38) 0.365
  1. aadjusted for age, sex smoking and alcohol drinking where appropriate, Add additive model, Dom dominant model, Rec recessive model, OR odds ratio, CI confidence interval.