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Table 3 The association between two SNPs within the FTO gene and the risk of tuberculosis

From: Obesity-associated gene FTO rs9939609 polymorphism in relation to the risk of tuberculosis

SNPs Control (n = 1544) Total cases (n = 1583) Smear-positive cases (n = 1077)
n (%) n (%) cOR (95% CI) P aOR (95% CI) P n (%) cOR (95% CI) P aOR (95% CI) P
rs9939609 (T > A)           
TT 1250(80.91) 1258(79.52) 1   1   856(79.48) 1   1  
AT 275(17.86) 253(15.94) 0.91(0.75-1.10) 0.316 0.91(0.74-1.10) 0.316 182(16.90) 0.96(0.78-1.18) 0.723 0.96(0.77-1.19) 0.699
AA 19(1.23) 72(4.54) 3.77(2.26-6.28) <0.001 3.57(2.13-6.01) <0.001 39(3.62) 2.99(1.73-5.17) <0.001 2.84(1.61-5.01) <0.001
T allele 2767(89.84) 2777(87.35) 1     1894(87.93) 1    
A allele 313(10.16) 397(12.51) 1.26(1.08-1.48) 0.004    260(12.07) 1.21(1.02-1.44) 0.030   
Add    1.23(1.06-1.42) 0.006 1.22(1.05-1.42) 0.011   1.20(1.01-1.41) 0.035 1.18(0.99-1.40) 0.059
Dom    1.10(0.92-1.31) 0.296 1.09(0.91-1.30) 0.374   1.10(0.90-1.34) 0.343 1.09(0.89-1.33) 0.424
Rec    3.82 (2.30-6.37) <0.001 3.64(2.17-6.10) <0.001   3.02(1.73-5.25) <0.001 2.86(1.62-5.04) <0.001
rs8050136 (C > A)           
CC 1250(80.91) 1265(79.96) 1   1   863(80.13) 1   1  
AC 282(18.31) 311(19.60) 1.09(0.91-1.30) 0.347 1.08(0.19-1.26) 0.408 210(19.5) 1.08(0.89-1.32) 0.448 1.07(0.87-1.32) 0.513
AA 12(0.78) 7(0.44) 0.58(0.23-1.47) 0.248 0.48(0.19-1.26) 0.136 4(0.37) 0.48(0.16-1.50) 0.209 0.40(0.13-1.28) 0.123
C allele 2774(90.06) 2849(89.76) 1     1936(89.88) 1    
A allele 306(9.94) 325(10.24) 1.03 (0.88-1.22) 0.690    218(10.12) 1.02(0.85-1.23) 0.826   
Add    1.04(0.88-1.23) 0.632 1.02(0.86-1.22) 0.804   1.03(0.85-1.24) 0.789 1.01(0.83-1.22) 0.957
Dom    1.07(0.90-1.28) 0.461 1.05(0.88-1.27) 0.569   1.06(0.87-1.28) 0.590 1.04(0.85-1.28) 0.702
Rec    0.57 (0.22-1.44) 0.234 0.48(0.18-1.24) 0.127   0.48(0.15-1.48) 0.200 0.40(0.12-1.26) 0.117*
  1. Add additive model, Dom dominant model, Rec recessive model, cOR crude odds ratio, CI confidence interval, aOR adjusted odds ratio, adjusted for age, sex smoking and alcohol drinking.