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Table 4 Associations between cervical HPV infection findings and serological reactivity for HPV16

From: Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study

HPV infection variable Categories HPV16 seroreactivity 425/1624 (%)* OR (95% CI)**
Unadjusted Age-adjusted
HPV16 DNA No 398/1593 (20.0) 1.0 1.0
Yes 27/30 (47.4) 3.60 (2.11-6.13) 3.86 (2.23-6.59)
HPV16 DNA Negative 398/1593 (20.0) 1.0 1.0
Single infection 19/20 (48.7) 3.80 (2.01-7.19) 3.93 (2.07-7.48)
Other types present 8/10 (44.4) 3.20 (1.25-8.17) 3.69 (1.44-9.47)
HPV16 viral load*** Negative 398/1593 (20.0) 1.0 1.0
<1 8/11 (42.1) 2.91 (1.16-7.28) 3.10 (1.23-7.79)
1-100 12/13 (48.0) 4.33 (1.96-9.58) 4.64 (2.09-10.3)
100+ 7/6 (53.9) 3.43 (1.14-10.3) 3.73 (1.24-11.2)
HPV18 DNA No 423/1605 (20.9) 1.0 1.0
Yes 2/18 (10.0) 0.42 (0.10-1.82) 0.45 (0.10-1.96)
HPV31 DNA No 420/1604 (20.8) 1.0 1.0
Yes 5/19 (20.8) 1.01 (0.37-2.71) 1.18 (0.43-3.21)
HPV33 DNA No 423/1616 (20.8) 1.0 1.0
Yes 2/7 (22.2) 1.09 (0.23-5.27) 1.13 (0.23-5.52)
HPV6/11 DNA No 420/1606 (98.9) 1.0 1.0
Yes 5/17 (1.1) 1.12 (0.41-3.06) 1.26 (0.46-3.44)
Non HPV16 Alpha PV 9**** No 400/1574 (20.3) 1.0 1.0
Yes 25/50 (33.3) 2.00 (1.20-3.21) 2.17 (1.32-3.56)
Alpha PV 7 No 412/1566 (20.8) 1.0 1.0
Yes 13/58 (18.3) 0.85 (0.46-1.57) 0.90 (0.49-1.67)
Alpha PV 3/15 No 416/1584 (20.8) 1.0 1.0
Yes 9/40 (18.4) 0.86 (0.41-1.78) 0.87 (0.41-1.81)
Any HPV No 338/1371 (19.8) 1.0 1.0
Yes 87/252 (25.7) 1.40 (1.07-1.83) 1.52 (1.15-1.83)
Any HPV (non-HPV16) No 338/1371 (19.8) 1.0 1.0
Yes 60/222 (21.3) 1.10 (0.80-1.49) 1.19 (0.88-1.64)
Any HR-HPV No 363/1466 (19.9) 1.0 1.0
Yes 62/157 (28.3) 1.60 (1.16-2.19) 1.73 (1.25-2.39)
Any LR-HPV No 400/1528 (20.8) 1.0 1.0
Yes 25/95 (20.8) 1.00 (0.63-1.58) 1.06 (0.67-1.67)
  1. *Frequencies above and below the threshold for the top 20% quintile and percentage with high seroreactivity; **Odds ratios and respective 95% confidence intervals. First category in each variable is the referent; ***Number of copies per cell; ****Alphapapillomavirus species 9 and other groupings: see text for details; viral load.