Safety and efficacy of amphotericin-B deoxycholate inhalation in critically ill patients with respiratory Candida spp. colonization: a retrospective analysis

Table 4 Multiple Cox proportional hazard modeling for duration of mechanical ventilation

	HR (95% CI)	P
ABDC treatment	3.63 (1.57-8.34)	0.003
Candida spp. load until day 5	1.19 (0.70-2.02)	0.51
Candida spp. load after day 5	0.67 (0.31-1.47)	0.32
Duration of colonization until day 5	0.96 (0.90-1.02)	0.13
Duration of colonization after day 5	0.92 (0.88-0.96)	<0.001
CPIS day 7	0.91 (0.76-1.10)	0.32
LIS day 7	0.60 (0.40-0.91)	0.02

Hazard ratios (HR; 95% confidence interval, CI) are given for each variable. Abbreviations: ABDC = amphotericin B deoxycholate; CPIS = clinical pulmonary infection score; LIS = lung injury score.

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