Table 2 Respiratory Candida spp. colonization, risk factors, bacterial infection and treatment characteristics starting day 1 of colonization in untreated group and from day 1 of colonization to start of treatment in treated group and thereafter, until ICU death or discharge
ABDC no Day 1 until ICU death or discharge, n = 62 | ABDC yes Day 1 to start treatment, n = 51 | P vs no | ABDC yes Day 1 until ICU death or discharge, n = 51 | P vs no | |
|---|---|---|---|---|---|
Total Candida spp. cultures respiratory tract 2 (1) | 3 (1) | 0.67 | 4 (3) | <0.001 | |
Candida spp. load | 0.46 | 0.36 | |||
Mild, <104 | 38 (61) | 32 (58) | 30 (60) | ||
Moderate, 104-105 | 13 (21) | 18 (33) | 16 (32) | ||
Heavy, >105 | 11 (18) | 5 (9) | 4 (8) | ||
Candida albicans | 41 (66) | 34 (61) | 0.45 | 32 (63) | 0.74 |
Candida non-albicans | 3 (4) | 1 (2) | 3 (6) | ||
Both Candida spp. | 18 (30) | 20 (37) | 16 (31) | ||
Duration of respiratory colonization, days | 5 (9) | 5 (5) | 0.66 | 12 (18) | <0.001 |
Corticosteroids | 23 (37) | 18 (35) | 0.85 | 22 (43) | 0.52 |
TPN | 21 (34) | 16 (31) | 0.78 | 18 (35) | 0.88 |
Ventilator-associated pneumonia, | 23 (37) | 11 (22) | 0.16 | 18 (35) | 0.96 |
Days after first Candida spp. culture | 4(6) | 3 (4) | 0.43 | 5(4) | 0.91 |
Gram positive | 6 (10) | 0 (0) | 2 (4) | ||
Gram negative | 17 (27) | 11 (22) | 16 (31) | ||
CPIS, day 1 | 7 (3) | 8 (2) | 0.10 | NA | NA |
day 7 | 5 (4) | NA | NA | 8 (3) | <0.001 |
Systemic antifungal treatment | 17 (27) | 13 (26) | 0.39 | 18 (35) | 0.93 |
Echinocandins | 11 (17) | 9 (18) | 11 (21) | ||
Azoles | 6 (10) | 4 (8) | 7 (14) |