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Table 2 Respiratory Candida spp. colonization, risk factors, bacterial infection and treatment characteristics starting day 1 of colonization in untreated group and from day 1 of colonization to start of treatment in treated group and thereafter, until ICU death or discharge

From: Safety and efficacy of amphotericin-B deoxycholate inhalation in critically ill patients with respiratory Candida spp. colonization: a retrospective analysis

  ABDC no Day 1 until ICU death or discharge, n = 62 ABDC yes Day 1 to start treatment, n = 51 P vs no ABDC yes Day 1 until ICU death or discharge, n = 51 P vs no
Total Candida spp. cultures respiratory tract 2 (1)   3 (1) 0.67 4 (3) <0.001
Candida spp. load    0.46   0.36
 Mild, <104 38 (61) 32 (58)   30 (60)  
 Moderate, 104-105 13 (21) 18 (33)   16 (32)  
 Heavy, >105 11 (18) 5 (9)   4 (8)  
Candida albicans 41 (66) 34 (61) 0.45 32 (63) 0.74
Candida non-albicans 3 (4) 1 (2)   3 (6)  
Both Candida spp. 18 (30) 20 (37)   16 (31)  
Duration of respiratory colonization, days 5 (9) 5 (5) 0.66 12 (18) <0.001
Corticosteroids 23 (37) 18 (35) 0.85 22 (43) 0.52
TPN 21 (34) 16 (31) 0.78 18 (35) 0.88
Ventilator-associated pneumonia, 23 (37) 11 (22) 0.16 18 (35) 0.96
 Days after first Candida spp. culture 4(6) 3 (4) 0.43 5(4) 0.91
 Gram positive 6 (10) 0 (0)   2 (4)  
 Gram negative 17 (27) 11 (22)   16 (31)  
CPIS, day 1 7 (3) 8 (2) 0.10 NA NA
 day 7 5 (4) NA NA 8 (3) <0.001
Systemic antifungal treatment 17 (27) 13 (26) 0.39 18 (35) 0.93
 Echinocandins 11 (17) 9 (18)   11 (21)  
 Azoles 6 (10) 4 (8)   7 (14)  
  1. Numbers (percentage) or median (interquartile range), where appropriate. Abbreviations: ABDC = amphotericin-B deoxycholate; TPN = total parenteral nutrition; CPIS = clinical pulmonary infection score; day 1 and 7 refer to day of first isolation of Candida spp. in respiratory secretions and 1 week later, respectively; NA = not applicable.