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Table 3 Associations with virologic failure (HIV-1 RNA >400 copies/mL) in 2012-13; univariate and multivariate analysis

From: Durability of antiretroviral therapy and predictors of virologic failure among perinatally HIV-infected children in Tanzania: a four-year follow-up

  Univariate analysis Multivariate analysis
Characteristic in 2012-13 Odds ratio P value Confidence interval Odds ratio P value Confidence interval
Female 1.582 0.205 0.778 - 3.218    
Age continuous (years) 1.223 <0.001 1.093 - 1.369 1.031 0.860 0.733 - 1.449
Age categorical (>12 years) 4.327 <0.001 1.908 - 9.814    
Time on Treatment 1.190 0.217 0.903 - 1.569    
Regimen 1st line AZT (d4T) +3TC + EFV 1 (reference)      
AZT (d4T) +3TC + NVP 1.291 0.642 0.441 - 3.780    
2nd line ABC +3TC + LPV/r 2.605 0.064 0.946 - 7.175    
Adherence (Poor) as reported by physician 4.974 <0.001 2.295 - 10.781 2.371 0.439 0.267 - 21.073
*Original HIV-1 RNA, log10copies/mL 1.148 0.108 0.970 - 1.357 1.765 0.324 0.570 - 5.467
CD4 continuous (mean) variable 0.997 <0.001 0.996 - 0.998 0.997 0.083 0.994 - 1.000
CD4 Categorical: <200 1 (reference)      
CD4 201-349 1.125 0.889 0.183 - 6.935    
CD4 350 - 499 0.429 0.346 0.073 - 2.500    
CD4 ≥ 500 0.083 0.001 0.019 - 0.367    
TAMs:       
0 1 (reference)      
1 3.333 0.183 0.567 - 19.593 2.349 0.458 0.247 - 22.376
≥ 2 3.75 0.183 0.537 - 26.188 3.376 0.502 0.096 - 118.12
  1. *This is the Original 2008-09 HIV-1 RNA.