Durability of antiretroviral therapy and predictors of virologic failure among perinatally HIV-infected children in Tanzania: a four-year follow-up

Table 3 Associations with virologic failure (HIV-1 RNA >400 copies/mL) in 2012-13; univariate and multivariate analysis

		Univariate analysis			Multivariate analysis
Characteristic in 2012-13		Odds ratio	P value	Confidence interval	Odds ratio	P value	Confidence interval
Female		1.582	0.205	0.778 - 3.218
Age continuous (years)		1.223	<0.001	1.093 - 1.369	1.031	0.860	0.733 - 1.449
Age categorical (>12 years)		4.327	<0.001	1.908 - 9.814
Time on Treatment		1.190	0.217	0.903 - 1.569
Regimen 1^st line	AZT (d4T) +3TC + EFV	1 (reference)
Regimen 1^st line	AZT (d4T) +3TC + NVP	1.291	0.642	0.441 - 3.780
2^nd line	ABC +3TC + LPV/r	2.605	0.064	0.946 - 7.175
Adherence (Poor) as reported by physician		4.974	<0.001	2.295 - 10.781	2.371	0.439	0.267 - 21.073
*Original HIV-1 RNA, log10copies/mL		1.148	0.108	0.970 - 1.357	1.765	0.324	0.570 - 5.467
CD4 continuous (mean) variable		0.997	<0.001	0.996 - 0.998	0.997	0.083	0.994 - 1.000
CD4 Categorical: <200		1 (reference)
CD4 201-349		1.125	0.889	0.183 - 6.935
CD4 350 - 499		0.429	0.346	0.073 - 2.500
CD4 ≥ 500		0.083	0.001	0.019 - 0.367
TAMs:
0		1 (reference)
1		3.333	0.183	0.567 - 19.593	2.349	0.458	0.247 - 22.376
≥ 2		3.75	0.183	0.537 - 26.188	3.376	0.502	0.096 - 118.12

ISSN: 1471-2334