Table 1 Cytokine concentrations in lung homogenates and plasma of WT and APC ^high -mice during pneumococcal pneumonia

TNF-α

8.6

7.6

249

284

217

56

(6.1-9.8)

(4.8-14)

(164–318)

(182–549)

(19–821)

(11–290)

IL-6

21

31

1218

1429

1317

694

(17–22)

(16–51)

(474–1522)

(1078–1992)

(650–1722)

(104–1449)

IL-10

16

24

17

12

20

19

(15–22)

(22–35)

(11–24)

(7.6-21)

(11–33)

(16–28)

IL-12p70

BD

BD

13

17

BD

BD

(5.4-21)

(11–49)

IFN-γ

BD

BD

12

19

14

13

(8.1-19)

(8.4-26)

(4.3-32)

(5.4-41)

MCP-1

254

210

2891

3239

4913

3056

(229–274)

(187–247)

(1935–3561)

(2507–4730)

(2901–5574)

(884–5958)

KC

255

221

4809

6838

8338

6993

(215–317)

(66–347)

(3548–7702)

(5165–9143)

(4703–10317)

(4421–8496)

KC (BALF)

117

102

255

277

231

236

(106–131)

(99–127)

(241–347)

(252–306)

(213–343)

(194–260)

WT

APC ^high

WT

APC ^high

WT

APC ^high

TNF-α

15

16

42

37

92

43

(13–20)

(13–18)

(36–53)

(29–46)

(48–111)

(23–74)

IL-6

5.1

3.9

331

263

795

223

(2.5-7.4)

(2.9-22)

(232–442)

(213–354)

(183–881)

(111–602)

IL-10

BD

BD

BD

BD

BD

BD

IL-12p70

7.8

10

11

27

6.9

6.0

(5.2-9.8)

(6.4-13)

(10–16)

(14–40)

(3.5-17)

(3.9-8.4)

IFN-γ

2.0

1.4

24

38

43

29

(1.9-2.1)

(1.3-6.7)

(14–41)

(23–55)

(30–69)

(8.2-82)

MCP-1

26

37

138

95

590

240

(26–41)

(35–42)

(71–196)

(83–149)

(402–786)

(138–786)