Risk of first cervical HPV infection and pre-cancerous lesions after onset of sexual activity: analysis of women in the control arm of the randomized, controlled PATRICIA trial

Table 2 Factors associated with risk of the first cervical HPVI or 6MPI (multivariable Cox proportional-hazards analysis)

Covariate	Category	HPVI				6MPI
		No. of women (N = 982)	No. of women with HPVI (N = 496)	HR (95% CI)	p-value	No. of women (N = 982)	No. of women with 6MPI (N = 281)	HR (95% CI)	p-value
Region	Europe	644	345	1		644	201	1
	Asia Pacific	168	58	1.11 (0.81-1.52)	0.5055	168	36	1.21 (0.78-1.86)	0.3995
	Latin America	76	46	1.16 (0.84-1.60)	0.3627	76	24	0.99 (0.63-1.57)	0.9773
	North America	94	47	0.88 (0.64-1.20)	0.4273	94	20	0.75 (0.47-1.20)	0.2283
				0.5498				0.4934
Number of lifetime sexual partners¹	1	800	234	1		800	127	1
	2-3	430	190	4.76 (3.82-5.95)	<0.0001	470	111	4.19 (3.12-5.63)	<0.0001
	≥4	125	72	19.22 (14.02-26.34)	<0.0001	166	43	14.14 (9.35-21.37)	<0.0001
				<0.0001				<0.0001
History of Chlamydia trachomatis during the past 12 months¹	No	977	463	1		978	257	1
	Yes	60	33	3.00 (2.07-4.36)	<0.0001	73	24	2.50 (1.57-4.00)	0.0001
				<0.0001				0.0001
Cumulative duration of hormone use for contraception or other indication¹	No use	804	105	1		804	59	1
	1-12 months	727	173	2.18 (1.68-2.83)	<0.0001	746	111	2.10 (1.48-2.98)	<0.0001
	13-48 months	536	206	3.26 (2.45-4.34)	<0.0001	590	108	2.79 (1.91-4.09)	<0.0001
	>48 months	56	11	5.42 (2.84-10.36)	<0.0001	69	2	1.62 (0.39-6.74)	0.5107
				<0.0001				<0.0001
Marital/partner status¹	Living or lived with partner	238	42	1		271	19	1
	Single	961	454	1.45 (1.04-2.04)	0.0291	963	262	1.75 (1.01-3.03)	0.0445
				0.0291				0.0445
Tobacco exposure (number of pack-years)¹	<0.5	862	402	1		862	223	1
	≥0.5	153	94	1.17 (0.92-1.47)	0.1936	161	58	1.22 (0.90-1.66)	0.2085
				0.1936				0.2085
Previous cervical HPV infection¹	No	-	-	-	-	965	231	1
	Yes	-	-	-	-	188	38	0.49 (0.33-0.72)	0.0003
				-				0.0003

¹Time-varying covariates. The number of women represents the number of observations that appeared at least once during the follow-up period. One woman can be counted in several categories. The number of events (HPVI or 6MPI) corresponds to the value recorded at the most recent visit before the endpoint.
Values in italics are the overall p-value.
Age at first sexual intercourse was not included in the multivariable analyses because p-values of >0.2 were obtained in the univariate analyses. The covariates of number of sexual partners during the past 12 months and hormone use or not for contraception or another indication were not included in the multivariable analyses because of overlap with the covariates of number of lifetime sexual partners and cumulative duration of hormone use or other indication, respectively.
6MPI: 6-month persistent HPV infection; CI: confidence interval; HPV: human papillomavirus; HPVI: HPV infection of any duration; HR: Hazard ratio.

ISSN: 1471-2334