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Table 1 Biochemical, histologic, virologic and serologic changes in response to experimental inoculation of nude mice with HEV

From: Experimental infection of Balb/c nude mice with Hepatitis E virus

Group   No.1 No.2 No.3
HEV-RNA (feces) 0d - - -
  4d - +(4/4) -
  7d - +(4/4) +(1/4)
  14d - +(4/4) +(1/4)
  21d - - -
  Liver - +(4/4) +(1/4)
  Spleen - +(4/4) +(1/4)
  Kidney - +(4/4) +(1/4)
HEV-antigen Jejunum - +(4/4) -
  Ileum - +(4/4) -
  Colon - +(4/4) -
Anti-HEV IgG   - +(4/4) +(1/4)
IHC   - +(4/4) +(1/4)
ALT   --- --- ---
AST   ---
ALP   ---
TBIL   --- --- ---
Histologic change   no change obvious obvious
  1. -: HEV RNA negative detected by RT-PCR; +: HEV RNA positive detected by RT-PCR; IgG: the positive proportions of HEV antibodies detected by ELISA 21 days post-inoculation; IHC: the positive proportions of HEV antigen detected by indirect immunofluorescence; ---: no significant changes; ↑: significantly elevated compared with a negative control.