Table 1 Biochemical, histologic, virologic and serologic changes in response to experimental inoculation of nude mice with HEV
From: Experimental infection of Balb/c nude mice with Hepatitis E virus
| Group | No.1 | No.2 | No.3 | |
|---|---|---|---|---|
| HEV-RNA (feces) | 0d | - | - | - |
| 4d | - | +(4/4) | - | |
| 7d | - | +(4/4) | +(1/4) | |
| 14d | - | +(4/4) | +(1/4) | |
| 21d | - | - | - | |
| Liver | - | +(4/4) | +(1/4) | |
| Spleen | - | +(4/4) | +(1/4) | |
| Kidney | - | +(4/4) | +(1/4) | |
| HEV-antigen | Jejunum | - | +(4/4) | - |
| Ileum | - | +(4/4) | - | |
| Colon | - | +(4/4) | - | |
| Anti-HEV IgG | - | +(4/4) | +(1/4) | |
| IHC | - | +(4/4) | +(1/4) | |
| ALT | --- | --- | --- | |
| AST | --- | ↑ | ↑ | |
| ALP | --- | ↑ | ↑ | |
| TBIL | --- | --- | --- | |
| Histologic change | no change | obvious | obvious |